(2R)-2-ethyl-2-methoxycarbonylhex-4-enoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R)-2-ethyl-2-methoxycarbonylhex-4-enoic acid
• 化学式: C₁₀H₁₆O₄
• 分子量: 200.23
• InChiKey: BGAQNUWZKPFKGP-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Novel chiral compounds derived from hexanoic acid esters, preparation process and intermediates, use in the synthesis of chiral 2-(bromomethyl)-2-ethylhexanoic acid
  申请人：Aventis Pharma S.A.

  公开号：US20040147774A1

  公开（公告）日：2004-07-29

  A subject matter of the invention is a chiral compound of formula 1 where R 1 is hydroxyl or a group which activates the carboxyl and R 2 is alkyl optionally substituted by halogen or benzyl, its preparation, its application in the synthesis of chiral 2-bromomethyl-2-ethylhexanoic acid and novel intermediates.

  本发明涉及一种手性化合物，其化学式为1，其中R1为羟基或活化羧基的基团，R2为烷基，可选择地被卤素或苄取代，以及其制备方法、在手性2-溴甲基-2-乙基己酸的合成中的应用以及新的中间体。
• NOVEL PROCESS FOR THE PREPARATION OF CHIRAL COMPOUNDS DERIVED FROM HEXANOIC ACID ESTERS AND INTERMEDIATES USED IN THE SYNTHESIS OF CHIRAL2-(BROMOMETHYL)-2-ETHYLHEXANOIC ACID
  申请人：CROCO-STUERGA Veronique

  公开号：US20080108847A1

  公开（公告）日：2008-05-08

  The present invention comprises a novel process for the preparation of a chiral compound of formula (I) wherein R 1 is hydroxyl or a group which activates the carboxyl and R 2 is alkyl optionally substituted by halogen or benzyl, its preparation, its application in the synthesis of chiral 2-bromomethyl-2-ethylhexanoic acid and novel intermediates.

  该发明涉及一种新的过程，用于制备公式（I）中的手性化合物，其中R1是羟基或活化羧基的基团，R2是烷基，可选地被卤素或苄基取代，其制备方法，其在手性2-溴甲基-2-乙基己酸的合成中的应用以及新的中间体。
• NOVEL PROCESS FOR THE PREPARATION OF CHIRAL COMPOUNDS DERIVED FROM HEXANOIC ACID ESTERS AND INTERMEDIATES USED IN THE SYNTHESIS OF CHIRAL-2-(BROMOMETHYL)-2-ETHYLHEXANOIC ACID
  申请人：Crocq-Stuerga Veronique

  公开号：US20100160670A1

  公开（公告）日：2010-06-24

  The present invention comprises a novel process for the preparation of a chiral compound of formula (I) wherein R 1 is hydroxyl or a group which activates the carboxyl and R 2 is alkyl optionally substituted by halogen or benzyl, its preparation, its application in the synthesis of chiral 2-bromomethyl-2-ethylhexanoic acid and novel intermediates.

  本发明涉及一种新型的制备手性化合物的方法，所述手性化合物的化学式为（I），其中R1为羟基或活化羧基的基团，R2为烷基，可以被卤素或苄基取代，本发明还涉及该手性化合物的制备方法，以及其在合成手性2-溴甲基-2-乙基己酸和新型中间体中的应用。
• NOVEL PROCESS FOR THE PREPARATION OF CHIRAL COMPOUNDS DERIVED FROM HEXANOIC ACID ESTERS AND INTERMEDIATES USED IN THE SYNTHESIS OF CHIRAL 2-(BROMOMETHYL)-2-ETHYLHEXANOIC ACID
  申请人：CROCQ-STUERGA Veronique

  公开号：US20090163737A1

  公开（公告）日：2009-06-25

  The present invention comprises a novel process for the preparation of a chiral compound of formula (I) wherein R 1 is hydroxyl or a group which activates the carboxyl and R 2 is alkyl optionally substituted by halogen or benzyl, its preparation, its application in the synthesis of chiral 2-bromomethyl-2-ethylhexanoic acid and novel intermediates.

  本发明涉及一种新型的制备手性化合物(I)的方法，其中R1为羟基或激活羧基的基团，R2为烷基，可选地被卤素或苄基取代，其制备方法，其在手性2-溴甲基-2-乙基己酸的合成中的应用以及新型中间体。