1-Azido-1,2,3,4,4a,8a-hexahydronaphthalene

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 1-Azido-1,2,3,4,4a,8a-hexahydronaphthalene
• 英文别名: 1-azido-1,2,3,4,4a,8a-hexahydronaphthalene
• 化学式: C10H13N3
• 分子量: 175.23
• InChiKey: UHRISCLKDZTOSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  14.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Triazoles and methods of use
  申请人：Aya Toshihiro

  公开号：US20060100213A1

  公开（公告）日：2006-05-11

  Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的化合物对于治疗疼痛和疾病，例如炎症介导性疾病具有有效性。本发明涵盖了新型化合物、类似物、前药和其药学上可接受的衍生物、制药组合物以及预防和治疗涉及疼痛、炎症等疾病和其他疾病或病况的方法。本发明还涉及制备这种化合物的过程以及在这种过程中有用的中间体。
• TRIAZOLES AND THEIR USE AS BRADYKININ B1 RECEPTOR ANTAGONISTS
  申请人：Amgen, Inc

  公开号：EP1817306A1

  公开（公告）日：2007-08-15
• US7612060B2
  申请人：——

  公开号：US7612060B2

  公开（公告）日：2009-11-03
• [EN] TRIAZOLES AND THEIR USE AS BRADYKININ B1 RECEPTOR ANTAGONISTS<br/>[FR] TRIAZOLES ET LEUR UTILISATION COMME ANTAGONISTES DU RECEPTEUR DE LA BRADYKININE B1
  申请人：AMGEN INC

  公开号：WO2006044355A1

  公开（公告）日：2006-04-27

  [EN] Compounds of Formula (I): are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
  [FR] L'invention concerne des composés de la formule (I), dans laquelle t représente 0, 1 ou 2; X est choisi parmi NH-, -S-, -O-, -NR