1-Methyl-1-pyrrol-1-ylurea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-Methyl-1-pyrrol-1-ylurea
• 英文别名: 1-methyl-1-pyrrol-1-ylurea
• 化学式: C₆H₉N₃O
• 分子量: 139.16
• InChiKey: KRPKQFPKXUWBQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• THIENOPYRROLE DERIVATIVES FOR USE IN TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF
  申请人：Biotheryx, Inc.

  公开号：EP3559005A1

  公开（公告）日：2019-10-30
• [EN] THIENOPYRROLE DERIVATIVES FOR USE IN TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF<br/>[FR] DÉRIVÉS DE THIÉNOPYRROLE DESTINÉS À ÊTRE UTILISÉS DANS LE CIBLAGE DE PROTÉINES, COMPOSITIONS, PROCÉDÉS ET UTILISATIONS ASSOCIÉS
  申请人：BIOTHERYX INC

  公开号：WO2018118947A1

  公开（公告）日：2018-06-28

  The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CKla, GSPTl, aiolos, and/or ikaros activity, and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of diseases, disorders, or conditions associated with a protein, such as diseases, disorders, and conditions associated with cytokines, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, and cancer, are provided.