3-p-tolyloxy-propionaldehyde | 91061-23-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-p-tolyloxy-propionaldehyde
• 英文别名: 3-(4-Methylphenoxy)-propanal；3-(4-Methylphenoxy)propanal
• CAS: 91061-23-3
• 化学式: C₁₀H₁₂O₂
• 分子量: 164.204
• InChiKey: KIHNJYKHOGMNJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-p-tolyloxy-propionaldehyde 、 乙基溴化镁 生成 (+/-)-1-p-Tolyloxy-pentanol-(3)
  参考文献：
  名称：

  Colonge,J. et al., Bulletin de la Societe Chimique de France, 1963, p. 553 - 557

  摘要：

  DOI：
• 作为产物：
  描述：

  3-p-Tolyloxy-propionaldehyd-semicarbazon 在 聚合甲醛 作用下， 生成 3-p-tolyloxy-propionaldehyde
  参考文献：
  名称：

  Colonge,J. et al., Bulletin de la Societe Chimique de France, 1963, p. 553 - 557

  摘要：

  DOI：

文献信息

• Tyrosine Bioconjugation through Aqueous Ene-Like Reactions
  申请人：The Scripps Research Institute

  公开号：US20140378668A1

  公开（公告）日：2014-12-25

  A new and versatile class of cyclic diazodicarboxamides that reacts efficiently and selectively with phenols and the phenolic side chain of tyrosine through an Ene-like reaction is reported. This mild aqueous tyrosine ligation reaction works over a broad pH range and expands the repertoire of aqueous chemistries available for small molecule, peptide, and protein modification. The tyrosine ligation reactions are shown to be compatible with the labeling of native enzymes and antibodies in buffered aqueous solution. This reaction provides a novel synthetic approach to bispecific antibodies. This reaction will find broad utility in peptide and protein chemistry and in the chemistry of phenol-containing compounds.

  报道了一种新型多功能环状二氮杂二羧酰胺类化合物，通过Ene类反应与苯酚和酪氨酸的苯基侧链高效选择性地反应。这种温和的水相酪氨酸连接反应适用于广泛的pH范围，并扩展了小分子、肽和蛋白质修饰的水相化学反应库。实验表明，酪氨酸连接反应与缓冲水溶液中的天然酶和抗体标记相容。该反应提供了一种新型的双特异性抗体合成方法，将在肽和蛋白质化学以及含酚化合物的化学中发挥广泛的实用性。
• CONTINUOUS ARYCYCLIC COMPOUND
  申请人：MITSUBISHI TANABE PHARMA CORPORATION

  公开号：US20160272614A1

  公开（公告）日：2016-09-22

  This is to provide a continuous arycyclic compound having a DGAT1 inhibitory activity, and useful for prophylaxis and/or treatment of obesity or hyperlipidemia caused by obesity, hypertriglyceridemia, lipid metabolism disorder, fatty liver, hypertension, arteriosclerosis, diabetes, etc., as well as to provide a DGAT1 inhibitor comprising the continuous arycyclic compound or a pharmaceutically acceptable salt thereof as an effective ingredient. Disclosed is the continuous arycyclic compound is represented by the formula: wherein the substituents in the formula are the same as defined in the specification, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种具有DGAT1抑制活性的连续芳环化合物，用于预防和/或治疗由肥胖、高甘油三酯血症、脂质代谢紊乱、脂肪肝、高血压、动脉硬化、糖尿病等引起的肥胖或高脂血症，以及提供一种以连续芳环化合物或其药学上可接受的盐为有效成分的DGAT1抑制剂。所披露的连续芳环化合物由以下式子表示：其中式子中的取代基与说明书中定义的相同，或其药学上可接受的盐。
• DIHYDROPYRONE COMPOUNDS AND HERBICIDES COMPRISING THE SAME
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150299156A1

  公开（公告）日：2015-10-22

  The present invention provides a compound having an excellent efficacy for controlling weeds. A dihydropyrone compound of formula (I): wherein m is 1, 2 or 3; n is an integer of any one of 1 to 5; X represents O, S, S(O) or S(O) 2 ; R 1 represents a hydrogen atom or a methyl group; R 2 and R 3 represents a hydrogen atom, an C 1-6 alkyl group and the like; when X represents S, S(O) or S(O) 2 , R 4 represents an C 1-6 alkyl group, a C 1-6 haloalkyl group, an C 6-10 aryl group or a five- to six-membered heteroaryl group, and X represents O, S, S(O) or S(O) 2 , R 4 represents an C 6-10 aryl group or a five- to six-membered heteroaryl group; G represents a hydrogen atom and the like; Z represents a halogen atom, a cyano group, a nitro group, a phenyl group, an C 1-6 alkyl group and the like; is useful as an active ingredient for herbicides.

  本发明提供了一种具有优异除草效果的化合物。该化合物为式（I）的二氢吡酮化合物：其中m为1、2或3；n为1至5的任一整数；X代表O、S、S（O）或S（O）2；R1代表氢原子或甲基基团；R2和R3代表氢原子、C1-6烷基基团等；当X代表S、S（O）或S（O）2时，R4代表C1-6烷基基团、C1-6卤代烷基基团、C6-10芳基基团或五元至六元杂环芳基基团，当X代表O、S、S（O）或S（O）2时，R4代表C6-10芳基基团或五元至六元杂环芳基基团；G代表氢原子等；Z代表卤原子、氰基、硝基、苯基、C1-6烷基基团等。该化合物可用作除草剂的活性成分。
• Compositions and methods for treating cardiovascular disease
  申请人：Genentech, Inc.

  公开号：US10787484B2

  公开（公告）日：2020-09-29

  The invention provides PCSK9 inhibitors, compositions comprising the PCSK9 inhibitors, and methods of identifying and using the PCSK9 inhibitors.

  本发明提供了 PCSK9 抑制剂、包含 PCSK9 抑制剂的组合物以及鉴定和使用 PCSK9 抑制剂的方法。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。