4-(2,4,4,5-Tetramethylhexan-2-yl)morpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-(2,4,4,5-Tetramethylhexan-2-yl)morpholine
• 英文别名: 4-(2,4,4,5-tetramethylhexan-2-yl)morpholine
• 化学式: C₁₄H₂₉NO
• 分子量: 227.39
• InChiKey: AILLSQXMOTYVHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• DIVERSITY-ORIENTED SYNTHESIS OF N,N,O-TRISUBSTITUTED HYDROXYLAMINES FROM ALCOHOLS AND AMINES BY N-O BOND FORMATION
  申请人：University of Georgia Research Foundation, Inc.

  公开号：US20210363098A1

  公开（公告）日：2021-11-25

  In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.

  在一个方面，该公开涉及一种通过N-O键形成直接合成复杂的N,N,O-三取代羟胺的方法。在另一个方面，该方法可以成功地利用各种商业可用的醇和二级胺，并实现构建基于大片段的三取代羟胺文库，用于药物发现目的。还公开了具有低碱性、在常温下高稳定性和固有缺乏对乙酰化和磺酰化酶的反应性的N,N,O-三取代羟胺，这些酶使得较少取代的羟胺具有致突变性。
• AMINOAMIDE COMPOUNDS
  申请人：BioTheryX, Inc.

  公开号：US20210145812A1

  公开（公告）日：2021-05-20

  Compounds with amino amide linkers and pharmaceutical compositions and medicaments comprising such compounds are disclosed. In addition, methods of making such compounds and their uses for treating or ameliorating diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.