N-phthaloyl glutamic acid α-methyl ester | 150823-38-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-phthaloyl glutamic acid α-methyl ester
• 英文别名: Phthaloylglutaminsaeure-α-methylester；N,N-phthaloyl-DL-glutamic acid-1-methyl ester；N,N-Phthaloyl-DL-glutaminsaeure-1-methylester；(S)-2-Phthalimido-4-(carboxy)butanoic acid, methyl ester；4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methoxy-5-oxopentanoic acid；4-(1,3-dioxoisoindol-2-yl)-5-methoxy-5-oxopentanoic acid
• CAS: 150823-38-4
• 化学式: C₁₄H₁₃NO₆
• 分子量: 291.26
• InChiKey: LUSYRXVDDWIUJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-phthaloyl glutamic acid α-methyl ester 生成 6-diazo-5-oxonorleucine
  参考文献：
  名称：

  6-Diazo-5-oxo-L-norleucine, a New Tumor-inhibitory Substance.^1a Preparation of L-, D- and DL-Forms^1b

  摘要：

  DOI：

  10.1021/ja01548a036
• 作为产物：
  描述：

  L-谷氨酸 在 甲醇 作用下， 生成 N-phthaloyl glutamic acid α-methyl ester
  参考文献：
  名称：

  6-Diazo-5-oxo-L-norleucine, a New Tumor-inhibitory Substance.^1a Preparation of L-, D- and DL-Forms^1b

  摘要：

  DOI：

  10.1021/ja01548a036

文献信息

• Synthesis and antitrypanosomal evaluation of some thiazole-containing amino acids and peptides
  作者：I Van Bogaert、A Haemers、W Bollaert、N Van Meirvenne、R Brun、K Smith、AH Fairlamb

  DOI：10.1016/0223-5234(93)90125-x

  日期：1993.1

  Several amino acids and peptides containing thiazole and thiazolidine residues were prepared. They were tested in vivo and in vitro as possible antitrypanosomal compounds. Some derivatives showed a slight activity. As they are structurally related to glutathione, their inhibitory properties towards glutathionylspermidine synthetase, trypanothione synthetase and trypanothione reductase were determined. No inhibitory activity was found.
• The Structure of Hydroxylysine
  作者：John C. Sheehan、William A. Bolhofer

  DOI：10.1021/ja01162a031

  日期：1950.6
• αε-Diamino-β-hydroxypimelic Acid. I. Synthesis of Isomer A
  作者：John M. Stewart、D. W. Woolley

  DOI：10.1021/ja01601a048

  日期：1956.10
• GPCR Ligands Identified by Computational Modeling
  申请人：Parrill-Baker Abby L.

  公开号：US20090029949A1

  公开（公告）日：2009-01-29

  Disclosed are pharmacophores for developing and screening compounds having G-protein-coupled receptor antagonist activity, including LPA 1 , LPA 2 , LPA 3 and S1P antagonists. These compositions have therapeutic benefit in the fields of cancer chemotherapy, cardiovascular disease prevention, and fertility protective agents during radiation and chemotherapy.
• 6-Diazo-5-oxo-L-norleucine, a New Tumor-inhibitory Substance.^1a Preparation of L-, D- and DL-Forms^1b
  作者：Horace A. DeWald、Alexander M. Moore

  DOI：10.1021/ja01548a036

  日期：1958.8