N-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-o-hydroxymethylbenzamide | 439288-43-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: N-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-o-hydroxymethylbenzamide
• 英文别名: N-(6,11-dihydro-5H-benzo[c][1]benzazepin-6-ylmethyl)-2-(hydroxymethyl)benzamide
• CAS: 439288-43-4
• 化学式: C₂₃H₂₂N₂O₂
• 分子量: 358.44
• InChiKey: PXRFSWYTNOQGNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  61.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-(苯二甲酰亚氨基甲基)吗吩烷啶 在 sodium tetrahydroborate 、 甲醇 作用下， 以 水 、 异丙醇 为溶剂， 反应 24.5h， 生成 N-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-o-hydroxymethylbenzamide
  参考文献：
  名称：

  METHOD FOR PREPARING 6-AMINOMETHYL-6,11-DIHYDRO-5H-DIBENZ(B,E)AZEPINE

  摘要：

  公开号：

  EP1496051B1

文献信息

• EP1496051A4
  申请人：——

  公开号：EP1496051A4

  公开（公告）日：2005-08-10
• Method for preparing 6-aminomethyl-6,11-dihydro-5h-dibenz[b,e]azepine
  申请人：Ikeda Shin

  公开号：US20050209215A1

  公开（公告）日：2005-09-22

  A production method of 6-aminomethyl-6,11-dihydro-5H-dibenz[b,e]azepin characterized in that said compound is produced via N-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-o-hydroxymethylbenzamide which is prepared by reducing 2-(11H-dibenz[b,e]azepin-6-ylmethyl)-1H-isoindole-1,3(2H)-dione employing a metal hydride or a metal hydride complex in a water based alcohol, and N-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-o-hydroxymethylbenzamide which is useful for the aforesaid production method.
• US7196193B2
  申请人：——

  公开号：US7196193B2

  公开（公告）日：2007-03-27
• [EN] METHOD FOR PREPARING 6-AMINOMETHYL-6,11-DIHYDRO-5H-DIBENZ[B,E]AZEPINE<br/>[FR] PROCEDE DE PREPARATION DE 6-AMINOMETHYL-6,11-DIHYDRO-5H-DIBENZ[B,E]AZEPINE
  申请人：KONICA CHEMICAL CORP

  公开号：WO2003084932A1

  公开（公告）日：2003-10-16

  A method for preparing 6-aminomethyl-6,11-dihydro-5H-dibenz[b,e]azepine, characterized in that it comprises reducing 2-(11H-dibenz[b,e]azepine-6-ylmethyl)-1H-isoindole-1,3(2H)-dione with a metal hydride or a metal hydrogen complex compound in an aqueous alcohol solvent, to form N-[(6,11-dihydro-5H-dibenz[b,e]azepine-6-yl)methyl]-o-hydroxymethylbenzamide; and N-[(6,11-dihydro-5H-dibenz[b,e]azepine-6-yl)methyl]-o-hydroxymethylbenzamide useful for the preparation.
• METHOD FOR PREPARING 6-AMINOMETHYL-6,11-DIHYDRO-5H-DIBENZ(B,E)AZEPINE
  申请人：Konica Minolta Chemical Co., Ltd.

  公开号：EP1496051B1

  公开（公告）日：2006-11-29