2-Amino-5-[[2-(carboxymethylamino)-2-oxo-1-(sulfanylmethyl)ethyl]amino]-5-oxo-pentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-5-[[2-(carboxymethylamino)-2-oxo-1-(sulfanylmethyl)ethyl]amino]-5-oxo-pentanoic acid
• 英文别名: 2-amino-5-[[1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
• 化学式: C20H34N6O12S2
• 分子量: 614.7
• InChiKey: WMYLYYNMCFINGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.41
• 重原子数：
  40
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  320
• 氢给体数：
  12
• 氢受体数：
  16

文献信息

• A new therapeutical composition containing apomorphine as active ingredient
  申请人：Britannia Pharmaceuticals Limited

  公开号：EP2545905A1

  公开（公告）日：2013-01-16

  The present invention relates to a pharmaceutical composition containing apomorphine as the active pharmaceutical ingredient, and more particularly a pharmaceutical formulation for parenteral administration, having a co-solvent, an anti-oxidant and a pH of greater than 4.

  本发明涉及一种含有阿朴吗啡作为活性药物成分的药物组合物，尤其是一种用于肠外给药的药物制剂，它具有助溶剂、抗氧化剂和大于 4 的 pH 值。
• ENHANCED STABILITY KETOROLAC FORMULATIONS AND METHODS AND DEVICES FOR USE WITH SAME
  申请人：Hurrey, Michael Laird

  公开号：EP3345592A1

  公开（公告）日：2018-07-11

  Provided is a unit dosage form of Ketorolac in a sterile fluid composition formulated for continuous subcutaneous delivery via body-worn infusion pump assembly, wherein said Ketorolac is present at a concentration of between 40 mg/mL and 240 mg/mL formulated for single use delivery in a volume not to exceed 1-10 mL, wherein said formulation is ethanol-free. Uses of same, body-worn infusion pump assemblies containing same and containers containing same for incorporation within a body-worn infusion pump assembly for a dose-sparing formulation comprising Ketorolac are also provided.

  本发明提供了一种无菌液体组合物中的酮咯酸单位剂型，配制成通过体外输液泵组件进行连续皮下给药，其中所述酮咯酸的浓度在40毫克/毫升至240毫克/毫升之间，配制成一次性使用的给药量不超过1-10毫升，其中所述制剂不含乙醇。此外，还提供了相同的用途、含有相同成分的贴身输液泵组件和含有相同成分的容器，用于在贴身输液泵组件中加入包含酮咯酸的剂量节省制剂。
• DOSE SPARING KETOROLAC FORMULATIONS AND METHODS AND DEVICES FOR USE WITH SAME
  申请人：Steadymed Ltd.

  公开号：EP3345598A1

  公开（公告）日：2018-07-11

  Provided is a unit dosage form of Ketorolac providing for a reduced dosage than typically provided to a subject in need of same, wherein said dosage form of Ketorolac is in a sterile fluid composition formulated for continuous subcutaneous delivery via body-worn infusion pump assembly, and wherein said Ketorolac is present at a concentration of between 40 mg/mL and 240 mg/mL formulated for single use delivery in a volume not to exceed 1-10 mL. Uses of same, body-worn infusion pump assemblies containing same and containers containing same for incorporation within a body-worn infusion pump assembly for a dose-sparing formulation comprising Ketorolac are also provided.

  本发明提供了一种酮咯酸的单位剂型，与通常提供给需要该剂型的受试者的剂量相比，其剂量有所减少，其中所述酮咯酸的剂型为无菌流体组合物，配制成通过体戴式输液泵组件连续皮下给药，且所述酮咯酸的浓度介于40 mg/mL和240 mg/mL之间，配制成一次性给药，给药量不超过1-10 mL。此外，还提供了相同的用途、含有相同成分的贴身输液泵组件和含有相同成分的容器，用于将其纳入贴身输液泵组件中，以获得包含酮咯酸的剂量节省制剂。
• Medication dispensing system
  申请人：Naheed Shabana

  公开号：US10064950B2

  公开（公告）日：2018-09-04

  A method for treating cancer is disclosed by boiling blended cannabis material with oil and collecting oil infused with cannabis; targeting cancerous cells in a body; and injecting the oil infused with cannabis into the body portion with cancerous cells.

  公开了一种治疗癌症的方法，该方法是将混合大麻材料与油一起煮沸，并收集浸泡有大麻的油；针对体内的癌细胞；以及将浸泡有大麻的油注入有癌细胞的身体部分。
• Medication system
  申请人：Naheed Shabana

  公开号：US10688190B2

  公开（公告）日：2020-06-23

  A method for delivering therapeutics includes infusing medication with cannabis.

  一种提供治疗的方法包括将药物注入大麻。