4-(5-Methylheptyl)morpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-(5-Methylheptyl)morpholine
• 英文别名: 4-(5-methylheptyl)morpholine
• 化学式: C₁₂H₂₅NO
• 分子量: 199.33
• InChiKey: UODJHRJGMHCVPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Biaryltriazole inhibitors of macrophage migration inhibitory factor
  申请人：YALE UNIVERSITY

  公开号：US10336721B2

  公开（公告）日：2019-07-02

  The present disclosure describes biaryl triazole compounds, as well as their compositions and methods of use. The compounds inhibit the activity of macrophage migration inhibitory factor and are useful for the treatment of diseases, e.g., inflammatory diseases and cancer.

  本公开介绍了双芳基三唑化合物及其组合物和使用方法。这些化合物抑制巨噬细胞迁移抑制因子的活性，可用于治疗疾病，如炎症性疾病和癌症。
• Biodegradable intravitreal tyrosine kinase implants
  申请人：Allergan, Inc.

  公开号：US10881608B2

  公开（公告）日：2021-01-05

  Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants can be placed in an eye to treat or reduce the occurrence of one or more ocular conditions.

  生物相容性眼内植入物包括一种酪氨酸激酶抑制剂和一种可生物降解的聚合物，可有效促进酪氨酸激酶抑制剂在眼球玻璃体内的长期释放。植入物的治疗剂可与生物可降解聚合物基质相关联，如基本不含聚乙烯醇的基质。可将植入物植入眼内，以治疗或减少一种或多种眼部疾病的发生。
• BIODEGRADABLE INTRAVITREAL TYROSINE KINASE IMPLANTS
  申请人：Allergan, Inc.

  公开号：US20190038551A1

  公开（公告）日：2019-02-07

  Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants can be placed in an eye to treat or reduce the occurrence of one or more ocular conditions,
• US9603895B2
  申请人：——

  公开号：US9603895B2

  公开（公告）日：2017-03-28