Palladium di(hydrogen L-glutamate)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Palladium di(hydrogen L-glutamate)
• 英文别名: (2S)-2-amino-5-hydroxy-5-oxopentanoate;palladium(2+)
• 化学式: C₁₀H₁₆N₂O₈Pd
• 分子量: 398.666
• InChiKey: BCPRJBFCDJQCAO-QHTZZOMLSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.15
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  207
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  在 silver nitrate 作用下， 以 水 为溶剂， 以65%的产率得到Palladium di(hydrogen L-glutamate)
  参考文献：
  名称：

  Interaction of Pd(II) with Glutamic Acid

  摘要：

  Pd(II) complexes with glutamic acid of the composition K[Pd(HGlu)Cl-2] (I) and [Pd(HGlu)(2)] (II) were synthesized and studied by IR and electronic absorption spectroscopy methods. Pd2+-H2O-Cl- and Pd2+-H2O-Cl--H(2)Glu systems were analyzed by pH-metric titration. The most essential Pd(II) complex forms were established by mathematical modeling and their formation constants were calculated. The electronic absorption spectra of complexes I and II were measured in aqueous and physiological solutions. Complex I was found to be biologically active and to exhibit antimetastatic properties.

  DOI：

  10.1023/b:ruco.0000037439.30356.e0

文献信息

• Synthesis, Characterization, and Non-Covalent Interactions of Palladium(II)-Amino Acid Complexes
  作者：David B. Hobart、Michael A. G. Berg、Hannah M. Rogers、Joseph S. Merola

  DOI：10.3390/molecules26144331

  日期：——

  The reaction of palladium(II) acetate with acyclic amino acids in acetone/water yields square planar bis-chelated palladium amino acid complexes that exhibit interesting non-covalent interactions. In all cases, complexes were examined by multiple spectroscopic techniques, especially HRMS (high resolution mass spectrometry), IR (infrared spectroscopy), and 1H NMR (nuclear magnetic resonance) spectroscopy

  乙酸钯 (II) 与无环氨基酸在丙酮/水中的反应产生方形平面双螯合钯氨基酸复合物，显示出有趣的非共价相互作用。在所有情况下，复合物都通过多种光谱技术进行了检查，尤其是 HRMS（高分辨率质谱）、IR（红外光谱）和1H NMR（核磁共振）光谱。在某些情况下，能够生长出适合单晶 X 射线衍射的晶体并获得分子结构。讨论了产品的分子几何形状。除丙氨酸配合物外，所有配合物都将水分子结合到扩展晶格中并表现出NH···O和/或O···(HOH)···O氢键相互作用。根据结构表现出的扩展晶格结构讨论非共价相互作用。
• Bis-Chelated Pd(II)-Amino Acid Complexes: Substitution Reactions of <i>cis</i>-Dichlorobis(benzonitrile)Palladium(II) with Amino Acids
  作者：Mukarram H. Zaghal、Manar S. Bani Saeed、Amer A. G. Abdel Hamid、Basem F. Ali

  DOI：10.1080/15533174.2013.819895

  日期：2015.2.1

  The substitution reactions of the benzonitrile (PhCN) complex cis-[Pd(PhCN)(2)C1(2)] with the sodium salts of some amino acids, namely L-tyrosine (tyrH), L-phenylalanine (pheH), L-glutamic acid (gluH), L-glutamine (glnH), L-cysteine (cysH), and glycine (glyH) have been investigated. The isolated complexes [Pd(tyr)(2)].0.5H(2)O, [Pd(phe)(2)].H2O, [Pd(glu)(2)], [Pd(gln)(2)].H2O, Na-2[Pd (cys)(2)].0.5Me(2)CO, and [Pd(gly)(2)].0.5H(2)O have been characterized by elemental analysis, conductivity measurements, IR, electronic absorption, and H-1- and C-13-NMR spectra. Based on these data, all amino acid anions are found to behave as bidentates through the -NH2 and -COO- groups except the cysteinate ion which bonds to Pd(II) through -NH2 and -S- groups.
• Wagner, Barbara; Taubald, Ute; Beck, Wolfgang, Chemische Berichte, 1989, vol. 122, p. 1031 - 1034
  作者：Wagner, Barbara、Taubald, Ute、Beck, Wolfgang

  DOI：——

  日期：——