2,18-Dihydroxyoctadecanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,18-Dihydroxyoctadecanoic acid
• 化学式: C₁₈H₃₆O₄
• 分子量: 316.5
• InChiKey: HOAVQQFRBCHZAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] NOVEL SESQUITERPENOID STAT3 INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DE STAT3 SESQUITERPÉNOÏDES
  申请人：UNIV HAWAII

  公开号：WO2014205416A1

  公开（公告）日：2014-12-24

  The present disclosure provides a method of purifying pharmaceutical compositions consisting essentially of STAT3 inhibitors from a mixture of compounds, pharmaceutical compositions comprising STAT3 inhibitors used to inhibit STAT3 in tumor cells, and certain pharmaceutically acceptable salts thereof, and methods of use. The present disclosure features, in some embodiments, novel, potent and selective STAT3 inhibitors, including sesquiterpene lactone inhibitors.

  本公开提供了一种从化合物混合物中纯化主要由STAT3抑制剂组成的药物组合物的方法，所述药物组合物包括用于抑制肿瘤细胞中的STAT3的STAT3抑制剂，以及其某些药用可接受的盐，以及使用方法。本公开在某些实施例中具有新颖、强效和选择性的STAT3抑制剂，包括倍半萜内酯抑制剂。
• PROCESS FOR PREPARING A CARBOXYLIC ACID FROM A DIOL OR FROM AN EPOXIDE BY OXIDATIVE CLEAVAGE
  申请人：SOCIETE INTEROLEAGINEUSE D'ASSISTANCE ET DE DEVELOPPEMENT (S.I.A.)

  公开号：US20150210623A1

  公开（公告）日：2015-07-30

  A process for preparing a carboxylic acid, by oxidative cleavage of at least one vicinal diol, or an epoxide, wherein the reaction is carried out in the presence of a catalyst and of an oxidizing agent and in the absence of solvent.

  通过氧化裂解至少一个邻二醇或环氧化物来制备羧酸的方法，其中反应在催化剂和氧化剂的存在下，在无溶剂的情况下进行。
• PROCESS FOR PREPARING ORGANICALLY MODIFIED SILOXANES
  申请人：Ferenz Michael

  公开号：US20070184006A1

  公开（公告）日：2007-08-09

  The invention provides a process for preparing siloxanes modified with organic esters, by hydrosilylating siloxanes with terminally unsaturated esters, which comprises preparing the terminally unsaturated esters used using at least one enzyme as catalyst.

  该发明提供了一种制备有机酯改性硅氧烷的方法，通过将硅氧烷与末端不饱和酯进行氢硅烷基化，其中包括使用至少一种酶作为催化剂来制备所使用的末端不饱和酯。
• [EN] OXIDATIVE CLEAVAGE OF OLEFINS, EPOXIDES AND ALCOHOLS<br/>[FR] CLIVAGE OXYDATIF D'OLÉFINES, D'ÉPOXYDES ET D'ALCOOLS
  申请人：RHODIA OPERATIONS

  公开号：WO2019015599A1

  公开（公告）日：2019-01-24

  Provided is a process for producing a compound I comprising at least one functional group chosen in the group consisting of epoxy group, hydroxyl group and carbonyl group and by reacting a compound J comprising at least one functional group chosen in the group consisting of alkenyl group, epoxy group and hydroxyl group with an an oxidant in the presence of solid amphiphilic catalytic particles A and solid amphiphilic catalytic particles B.

  提供的是一种生产化合物I的方法，其中化合物I至少包含在环氧基团、羟基和羰基中选择的至少一个官能团，并通过将含有烯基基团、环氧基团和羟基中选择的至少一个官能团的化合物J与氧化剂在固体两性催化颗粒A和固体两性催化颗粒B的存在下反应。
• Process for the enzymatic synthesis of pyroglutamic esters
  申请人：Pascaly Matthias

  公开号：US20060074259A1

  公开（公告）日：2006-04-06

  A process for the preparation of compounds according to the general formula (I), in which R is a hydrocarbon radical of an alcohol, wherein one or more alcohols of the general formula (II) R—OH  (II) in which R is as defined above, are esterified and/or transesterified without using significant amounts of solvents, preferably without solvents, preferably under reduced pressure at temperatures below 100° C. in the presence of enzymes from the class of hydrolases with a compound according to the general formula (III), in which R 1 is either hydrogen or a linear or branched alkyl or alkenyl group having 1 to 3 carbon atoms is provided.

  根据通式(I)的一般公式制备化合物的方法，其中R是醇的烃基，其中通式(II)R—OH的一个或多个醇在不使用大量溶剂的情况下酯化和/或酯交换，最好是无溶剂，最好在低于100°C的温度下在减压条件下，在水解酶类酶的存在下与通式(III)的化合物一起提供，其中R1是氢或具有1到3个碳原子的直链或支链烷基或烯烃基。