3-Cyclohexa-1,4-dien-1-ylprop-2-enoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-Cyclohexa-1,4-dien-1-ylprop-2-enoic acid
• 化学式: C₉H₁₀O₂
• 分子量: 150.17
• InChiKey: BICRLKUDLCTJHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• BIOCATALYST FOR CATALYTIC HYDROAMINATION
  申请人：Hauer Bernhard

  公开号：US20120123155A1

  公开（公告）日：2012-05-17

  The present invention relates to a method for the enzymatic hydroamination of C—C double bonds catalyzed by enzymes structurally and/or functionally related to phenylalanine ammonia lyase (PAL) isolated from microorganisms of Petroselinum crispum, Rhodoturula glutinis and/or functional active derivatives thereof.

  本发明涉及一种由与从欧芹、红曹霉等微生物中分离的结构和/或功能上与苯丙氨酸氨基裂解酶（PAL）相关的酶催化的C—C双键的酶促水氨化方法。
• Stabilization of L-phenylalanine ammonia-lyase enzyme
  申请人：Monsanto Company

  公开号：EP0136996A2

  公开（公告）日：1985-04-10

  A process for the synthesis of L-phenylalanines and analogues thereof from trans-cinnamate, ring substituted trans-cinnamates or various acrylate derivatives and ammonia or an ammonia donor in the presence of L-phenylalanine ammonia-lyase enzyme and a desensitizing agent such as polyhydric alcohols and polyethylene glycol-(400) is disclosed. The process embraces the discovery that compounds such as polyhydric alcohols and polyethylene glycol-(400) desensitize the L-phenyalanine ammonia-lyase enzyme to substantially higher substrate concentrations than practiced heretofore. In addition, polyhydric alcohols and polyethylene glycol-(400) substantially enhance the instantaneous rate of reaction and inhibit inactivation of the L-phenylalanine ammonia lyase enzyme over longer reaction periods.

  本发明公开了一种由反式肉桂酸酯、环取代的反式肉桂酸酯或各种丙烯酸酯衍生物和氨或氨供体在L-苯丙氨酸氨化酶和脱敏剂（如多元醇和聚乙二醇-(400)）存在下合成L-苯丙氨酸及其类似物的工艺。该工艺发现，多羟基乙醇和聚乙二醇-(400)等化合物可使 L-苯丙氨酸氨解酶脱敏，使其对底物浓度的要求大大高于以往的做法。此外，多元醇和聚乙二醇-(400)还能大大提高反应的瞬时速度，并在较长的反应时间内抑制 L-苯丙氨酸氨解酶的失活。
• Biocatalyst for catalytic hydroamination
  申请人：BASF SE

  公开号：EP2280075A1

  公开（公告）日：2011-02-02

  The present invention relates to a method for the enzymatic hydroamination of C-C double bonds catalyzed by enzymes structurally and/or functionally related to phenylalanine ammonia lyase (PAL) isolated from microorganisms of Petroselinum crispum, Rhodoturula glutinis and/or functional active derivatives thereof.

  本发明涉及一种C-C双键的酶法氢化方法，该方法由从芹菜、谷氨酰胺和/或其功能活性衍生物的微生物中分离出来的与苯丙氨酸氨裂解酶（PAL）结构和/或功能相关的酶催化。
• US4562151A
  申请人：——

  公开号：US4562151A

  公开（公告）日：1985-12-31
• [EN] BIOCATALYST FOR CATALYTIC HYDROAMINATION<br/>[FR] BIOCATALYSEUR DESTINÉ À UNE HYDROAMINATION CATALYTIQUE
  申请人：BASF SE

  公开号：WO2011012632A2

  公开（公告）日：2011-02-03

  The present invention relates to a method for the enzymatic hydroamination of C-C double bonds catalyzed by enzymes structurally and/or functionally related to phenylalanine ammonia lyase (PAL) isolated from microorganisms of Petroselinum crispum, Rhodoturula glutinis and/or functional active derivatives thereof.