5-[(10R)-10-hydroxytetradec-8-enyl]sulfanylpentanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-[(10R)-10-hydroxytetradec-8-enyl]sulfanylpentanoic acid
• 化学式: C₁₉H₃₆O₃S
• 分子量: 344.6
• InChiKey: LZMRYRDYNOLYFG-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  23
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  82.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Hydroxyeicosenoic acid anaglogs
  申请人：Falck R. John

  公开号：US20050038259A1

  公开（公告）日：2005-02-17

  A hydroxyeicosenoic acid analog represented by the following Formula (I), the bond ≡ represents a cis-vinylene group or an ethynylene group; Y represents CH 2 , O or S(O) p wherein p is 0, 1 or 2; m represents an integer of 1 to 4 inclusive; n represents an integer of 0 to 3 inclusive; the sum of m and n is an integer of 3 to 7 inclusive; R 1 represents a C 1-4 alkyl group or a C 3-8 cycloalkyl group; R 2 represents a hydrogen atom or a methyl group; R 3 represents COR 4 , a nitrile group, a halogen atom, a tetrazole group or a thiazolidinedione group; R 4 represents OR 6 , NHR 6 , N(OH)R 6 , NHSO 2 R 5 , glycerol or functionalized glycerols; R 5 represents a C 1-15 alkyl group, a C 6-10 aryl group or a C 7-14 aryl group substituted with alkyl groups, halogens or amino groups; R 6 represents a hydrogen, a C 1-10 alkyl group or a C 1-10 alkyl group substituted with a hydroxyl group, or a pharmaceutically acceptable salt or hydrate thereof. The compounds of the present invention are useful as an elastase release inhibitor.

  一种羟基二十烯酸类似物，由以下公式（I）表示，其中键≡表示顺式乙烯基或乙炔基；Y表示CH2，O或S（O）p，其中p为0，1或2；m表示1到4之间的整数；n表示0到3之间的整数；m和n的总和为3到7之间的整数；R1表示C1-4烷基或C3-8环烷基；R2表示氢原子或甲基基团；R3表示COR4，腈基，卤素原子，四唑基或噻唑烷二酮基；R4表示OR6，NHR6，N（OH）R6，NHSO2R5，甘油或功能化甘油；R5表示C1-15烷基，C6-10芳基或C7-14芳基，被烷基，卤素或氨基取代；R6表示氢，C1-10烷基或C1-10烷基，被羟基取代，或其医药上可接受的盐或水合物。本发明的化合物可用作弹性蛋白酶释放抑制剂。
• EP1425258A4
  申请人：——

  公开号：EP1425258A4

  公开（公告）日：2005-02-16
• HYDROXYEICOSENOIC ACID ANALOGS
  申请人：TAISHO PHARMACEUTICAL CO., LTD

  公开号：EP1425258A2

  公开（公告）日：2004-06-09
• [EN] HYDROXYEICOSENOIC ACID ANALOGS<br/>[FR] ANALOGUES DE L'ACIDE HYDROXYEICOSENOIQUE
  申请人：TAISHO PHARMA CO LTD

  公开号：WO2003024390A2

  公开（公告）日：2003-03-27

  A hydroxyeicosenoic acid analog represented by the following Formula (I), the bond represents a cis-vinylene group or an ethynylene group; Y represents CH2, O or S(O)p wherein p is 0, 1 or 2; m represents an integer of 1 to 4 inclusive; n represents an integer of 0 to 3 inclusive; the sum of m and n is an integer of 3 to 7 inclusive; R1 represents a C1-4 alkyl group or a C3-8 cycloalkyl group; R2 represents a hydrogen atom or a methyl group; R3 represents COR4, a nitrile group, a halogen atom, a tetrazole group or a thiazolidinedione group; R4 represents OR6, NHR6, N(OH)R?6, NHSO2R5¿, glycerol or functionalized glycerols; R5 represents a C¿1-15? alkyl group, a C6-10 aryl group or a C7-14 aryl group substituted with alkyl groups, halogens or amino groups; R?6¿ represents a hydrogen, a C¿1-10? alkyl group or a C1-10 alkyl group substituted with a hydroxyl group, or a pharmaceutically acceptable salt or hydrate thereof. The compounds of the present invention are useful as an elastase release inhibitor.