6-氯-3,4-二羟基-2H-1-苯并吡喃-2-酮 | 103620-90-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 6-氯-3,4-二羟基-2H-1-苯并吡喃-2-酮
• 英文名称: 6-Chloro-3,4-dihydroxy-2H-1-benzopyran-2-one
• 英文别名: 6-chloro-3,4-dihydroxychromen-2-one
• CAS: 103620-90-2
• 化学式: C₉H₅ClO₄
• 分子量: 212.58
• InChiKey: SJNXVIWLNZXABC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl 5-chloro-β-oxo-α,2-bis(phenylmethoxy)benzenepropanoate 在 钯 作用下， 以 乙酸乙酯 为溶剂， 反应 2.0h， 以affording 0.293 g (69%) of 6-chloro-3,4-dihydroxy-2H-1-benzopyran-2-one as white solid的产率得到6-氯-3,4-二羟基-2H-1-苯并吡喃-2-酮
  参考文献：
  名称：

  Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-dihydro

  摘要：

  本发明涉及一种新型苯并吡喃酮酸还原酮化合物，其化学式为I，其中X和Y从包括H（除非X和Y不是H，除非另有说明）、Cl或其他卤素、OH、直链或支链C.sub.1-C.sub.6烷基或烷氧基或苯基或苯氧基等的群体中选择，例如苯基或叔丁基等。本发明还提供了化学式I中X，Y=OCH.sub.2 O的化合物。本发明的化合物在治疗或预防血栓栓塞性疾病方面具有用途。

  公开号：

  US04845121A1

文献信息

• COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES
  申请人：Johansen Lisa M.

  公开号：US20100009970A1

  公开（公告）日：2010-01-14

  The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.

  本发明涉及用于治疗病毒性疾病的组合物、方法和试剂盒。在某些实施方式中，病毒性疾病是由单链RNA病毒、黄病毒科病毒或肝病毒引起的。在特定实施方式中，病毒性疾病是病毒性肝炎（例如甲型肝炎、乙型肝炎、丙型肝炎、丁型肝炎、戊型肝炎），药剂或药剂组合包括舍曲林、舍曲林类似物、UK-416244或UK-416244类似物。还包括用于鉴定可用于治疗病毒性疾病的新化合物的筛选方法。
• WITIAK DONALD T., KIM SUNG K., FELLER DENNIS R., ROMSTEDT KARL J.
  作者：WITIAK DONALD T., KIM SUNG K., FELLER DENNIS R., ROMSTEDT KARL J.

  DOI：——

  日期：——
• WITIAK D. T.; KIM SUNG K.; ROMSTEDT K.; NEWMAN H. A. I.; FELLER D. R., J. MED. CHEM., 29,(1986) N 11, 2170-2174
  作者：WITIAK D. T.、 KIM SUNG K.、 ROMSTEDT K.、 NEWMAN H. A. I.、 FELLER D. R.

  DOI：——

  日期：——
• Compositions and methods for treatment of viral diseases
  申请人：Johansen Lisa M.

  公开号：US20080161324A1

  公开（公告）日：2008-07-03

  The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E). Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.
• Drug for Treating Circulatory Insufficiency
  申请人：Takagaki Hidetsugu

  公开号：US20090099256A1

  公开（公告）日：2009-04-16

  The present invention relate to a drug for treating circulatory insufficiency containing a benzopyran derivative represented by the following general formula (I): and/or a physiologically acceptable salt thereof as an active ingredient, wherein R 1 is an alkyl group having 1 to 10 carbon atoms, or an alkenyl group having 2 to 10 carbon atoms; and any one of R 2 , R 3 , R 4 and R 5 is a hydroxyl group, an alkoxy group, an alkenyloxy group, an alkoxy group substituted with a hydroxyl group, or an alkoxy group substituted with a carboxy group, and the others are hydrogen atoms.