2-[4-(Carboxymethyl)-10-ethyl-7-(2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[4-(Carboxymethyl)-10-ethyl-7-(2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
• 英文别名: 2-[4-(carboxymethyl)-10-ethyl-7-(2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
• 化学式: C₁₆H₃₀N₄O₅
• 分子量: 358.43
• InChiKey: IMXKTOBHMPDSKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.3
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• RADIOACTIVE IMIDAZOTHIADIAZOLE DERIVATIVE COMPOUND
  申请人：Nihon Medi-Physics Co., Ltd

  公开号：EP3845541A1

  公开（公告）日：2021-07-07

  The present invention provides a radiolabeled compound represented by the following formula (1), which is a radioactive imidazothiadiazole derivative compound having an affinity for CA-IX, or a salt thereof. wherein n is an integer of 1 to 4, and L represents a radionuclide or a mono- to tetravalent group containing a radionuclide.

  本发明提供了由下式（1）表示的放射性标记化合物，它是一种对 CA-IX 具有亲和力的放射性咪唑噻二唑衍生物化合物或其盐。 其中 n 为 1 至 4 的整数，L 代表放射性核素或含有放射性核素的单价至四价基团。
• METHOD FOR PREPARING 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID
  申请人：Viwit Pharmaceutical Co., Ltd.

  公开号：EP3564218B1

  公开（公告）日：2021-02-24
• [EN] HIGHLY FLUORINATED OILS AND SURFACTANTS AND METHODS OF MAKING AND USING SAME<br/>[FR] HUILES ET TENSIOACTIFS HAUTEMENT FLUORÉS ET PROCÉDÉS DE FABRICATION ET D'UTILISATION DE CEUX-CI
  申请人：UNIV UTAH RES FOUND

  公开号：WO2007112100A2

  公开（公告）日：2007-10-04

  [EN] Disclosed are compounds comprising the structure (I): In one aspect, the compounds exhibit maximum symmetric branching. Also disclosed are bilayers, micelles, coatings, and nanoparticles comprising the disclosed compounds. Also disclosed are processes for the preparation of the disclosed compounds and methods of using the disclosed compounds. Also disclosed are highly fluorinated dendrons and methods for making same. Also disclosed are methods for Fluorous Mixture Synthesis and tagging. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
  [FR] L'invention concerne des composés comprenant la structure (I). Dans un aspect, les composés présentent une ramification symétrique maximum. L'invention concerne aussi des bicouches, des micelles, des revêtements et des nanoparticules comprenant les composés décrits; des procédés de préparation des composés décrits et des procédés d'utilisation de ceux-ci; des dendrimères hautement fluorés et des procédés de fabrication de ceux-ci; des procédés de synthèse de mélanges fluorés et de marquage. L'abrégé constitue un outil de recherche destiné à une technologie particulière et ne saurait en aucun cas limiter l'invention.
• [EN] REACTIVE CONJUGATES<br/>[FR] CONJUGUÉS RÉACTIFS
  申请人：[en]DEBIOPHARM RESEARCH & MANUFACTURING S.A.

  公开号：WO2022078566A1

  公开（公告）日：2022-04-21

  The present invention relates to compounds (reactive conjugates) for the chemical modification of therapeutic antibodies or proteins. The compounds enable the regioselective attachment of payloads to an antibody or antibody fragment in one single step, thereby producing a modified antibody or modified antibody fragment, which can be used for diagnosing, monitoring, imaging or treating disease.