7T6RG9Rde4 | 781571-75-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 7T6RG9Rde4
• 英文别名: 3-prop-2-enoxypropane-1-sulfonic acid
• CAS: 781571-75-3
• 化学式: C₆H₁₂O₄S
• 分子量: 180.22
• InChiKey: XRPAMYMNZKMOLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  72
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] NEW PROCESS<br/>[FR] NOUVEAU PROCEDE
  申请人：ASTRAZENECA AB

  公开号：WO2003045896A1

  公开（公告）日：2003-06-05

  The present invention relates to a new process for the preparation of the (S)-naproxen 4-nitrooxybutyl ester and to new intermediates obtained and used therein. The invention further relates to the use of the new intermediates for the manufacturing of pharmaceutically active compounds such as (S)-naproxen 4-nitrooxybutyl ester.The invention also relates to the use of (S)-naproxen 4-nitrooxybutyl ester prepared according to the process of the present invention for the manufacturing of a medicament for the treatment of pain.

  本发明涉及一种制备(S)-萘普生4-硝氧丁酯的新工艺，以及在该工艺中获得和使用的新中间体。本发明进一步涉及使用新中间体制造药物活性化合物，如(S)-萘普生4-硝氧丁酯。本发明还涉及使用按照本发明工艺制备的(S)-萘普生4-硝氧丁酯制造治疗疼痛的药物。
• HYDROGEL AND USES THEREFOR
  申请人：Sekisui Kasei Co., Ltd.

  公开号：EP3845606A1

  公开（公告）日：2021-07-07

  The present invention relates to a hydrogel and use thereof. More specifically, the present invention relates to a hydrogel comprising water and a polymer matrix, wherein the polymer matrix comprises a copolymer of a monofunctional monomer having a hydrophilic group and one ethylenic unsaturated group, and a polyfunctional monomer having no ester bond, and having an amide group and 3 to 6 ethylenic unsaturated groups, 40 to 95 parts by mass of the water, and 5 to 60 parts by mass of the polymer matrix are contained in 100 parts by mass of the hydrogel, and the hydrogel shows a swelling degree of 650% or less, when the hydrogel is immersed in a 4M aqueous KOH solution under a temperature of 25°C for 14 days, and use thereof.

  本发明涉及一种水凝胶及其用途。更具体地说，本发明涉及一种由水和聚合物基质组成的水凝胶，其中聚合物基质包括具有一个亲水基团和一个乙烯基不饱和基团的单官能团单体与无酯键、具有一个酰胺基团和 3 至 6 个乙烯基不饱和基团的多官能团单体的共聚物、在 100 重量份的水凝胶中含有 40 至 95 重量份的水和 5 至 60 重量份的聚合物基质，当水凝胶在 25°C 温度下的 4M KOH 水溶液中浸泡 14 天时，水凝胶的溶胀度为 650% 或更低，以及水凝胶的用途。
• Process
  申请人：Belli Aldo

  公开号：US20050234123A1

  公开（公告）日：2005-10-20

  At the present invention relates to a new process for the preparation of the (S)-naproxen 4-nitrooxybutyl ester and to new intermediates obtained and used therein. The invention further relates to the use of the new intermediates for the manufacturing of pharmaceutically active compounds such as (S)-naproxen 4-nitrooxybutyl ester. The invention also relates to the use of (S)-naproxen 4-nitrooxybutyl ester prepared according to the process of the present invention for the manufacturing of a medicament for the treatment of pain.

  本发明涉及一种制备(S)-那普生 4-硝基氧丁酯的新工艺以及由此获得和使用的新中间体。本发明还涉及新中间体在生产(S)-那普生 4-硝基氧丁酯等药物活性化合物中的用途。本发明还涉及根据本发明工艺制备的(S)-那普生 4-硝基氧丁酯用于生产治疗疼痛的药物的用途。
• NEW PROCESS
  申请人：AstraZeneca AB

  公开号：EP1451140A1

  公开（公告）日：2004-09-01
• SULFONATFUNKTIONELLE POLYVINYLACETALE
  申请人：Wacker Polymer Systems GmbH & Co. KG

  公开号：EP1763543B1

  公开（公告）日：2007-10-31