(2S)-1-[(2S)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-1-[(2S)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide
• 化学式: C₃₆H₄₇N₅O₄
• 分子量: 613.8
• InChiKey: CBVCZFGXHXORBI-XUBSOONYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  45
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Multiple drug lipid nanoparticle composition and related methods for extended drug levels in blood and lymph tissue
  申请人：University of Washington

  公开号：US10799456B2

  公开（公告）日：2020-10-13

  Provided are multi-drug lipid nanoparticles that stably incorporate multiple small molecule drugs with divergent hydrophobic and water solubility characteristics and related methods of making and using the same, The disclosed compositions and methods provide for enhanced stability of lipid nanoparticle drug formulations that can reliably provide drugs addressing different mechanistic targets with prolonged presence in the body for more efficacious treatment and avoidance of single drug resistance.

  所公开的组合物和方法提高了脂质纳米粒子药物制剂的稳定性，可以可靠地提供针对不同机理靶点的药物，并在体内长期存在，从而提高治疗效果，避免单药耐药性。
• MULTIPLE DRUG LIPID NANOPARTICLE COMPOSITION AND RELATED METHODS FOR EXTENDED DRUG LEVELS IN BLOOD AND LYMPH TISSUE
  申请人：University of Washington

  公开号：US20190350853A1

  公开（公告）日：2019-11-21

  Provided are multi-drug lipid nanoparticles that stably incorporate multiple small molecule drugs with divergent hydrophobic and water solubility characteristics and related methods of making and using the same, The disclosed compositions and methods provide for enhanced stability of lipid nanoparticle drug formulations that can reliably provide drugs addressing different mechanistic targets with prolonged presence in the body for more efficacious treatment and avoidance of single drug resistance.