2,2,4-trimethyl-4-(tertiobutyldimethylsilyloxy)methyloxazolidine | 160425-90-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 2,2,4-trimethyl-4-(tertiobutyldimethylsilyloxy)methyloxazolidine
• 英文别名: Tert-butyl-dimethyl-[(2,2,4-trimethyl-1,3-oxazolidin-4-yl)methoxy]silane
• CAS: 160425-90-1
• 化学式: C₁₃H₂₉NO₂Si
• 分子量: 259.464
• InChiKey: AMUCMWBKABENMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.12
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2,4-trimethyl-4-(tertiobutyldimethylsilyloxy)methyloxazolidine 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 以18.2%的产率得到2,2,4-trimethyl-4-(tertiobutyldimethylsilyloxy)methyloxazolidin-3-oxyl
  参考文献：
  名称：

  Nitroxides: Synthesis and paramagnetic properties of an α-hydroxymethyl derivative of DOXYL

  摘要：

  The synthesis of new but unstable alpha-(hydroxymethyl)oxazolidin-3-oxyls was achieved after protection by silylation of the hydroxyl groups in order to avoid decomposition in diamagnetic nitrones. Relaxivity studies of (R,S)-4-(hydroxymethyl)-2,2,4-trimethyloxazolidin-3-oxyl 1 show no beneficial effect due to the presence of an hydroxymethyl group in the vicinity of the N-O group on the paramagnetic properties of nitroxides.

  DOI：

  10.1016/s0040-4020(01)81211-4
• 作为产物：
  描述：

  叔丁基二甲基氯硅烷 、 2,2,4-trimethyl-4-(hydroxymethyl)oxazolidine 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 反应 30.0h， 以72%的产率得到2,2,4-trimethyl-4-(tertiobutyldimethylsilyloxy)methyloxazolidine
  参考文献：
  名称：

  Nitroxides: Synthesis and paramagnetic properties of an α-hydroxymethyl derivative of DOXYL

  摘要：

  The synthesis of new but unstable alpha-(hydroxymethyl)oxazolidin-3-oxyls was achieved after protection by silylation of the hydroxyl groups in order to avoid decomposition in diamagnetic nitrones. Relaxivity studies of (R,S)-4-(hydroxymethyl)-2,2,4-trimethyloxazolidin-3-oxyl 1 show no beneficial effect due to the presence of an hydroxymethyl group in the vicinity of the N-O group on the paramagnetic properties of nitroxides.

  DOI：

  10.1016/s0040-4020(01)81211-4

文献信息

• Aziz Chaouni-Benabdallah, Guy Subra, Pierre A. Bonnet, Jean P. Fernandez,+, Tetrahedron, 50 (1994) N 45, S 12923-12932
  作者：Aziz Chaouni-Benabdallah, Guy Subra, Pierre A. Bonnet, Jean P. Fernandez,+

  DOI：——

  日期：——
• Nitroxides: Synthesis and paramagnetic properties of an α-hydroxymethyl derivative of DOXYL
  作者：Aziz Chaouni-Benabdallah、Guy Subra、Pierre A. Bonnet、Jean P. Fernandez、Jean P. Chapat、Patrick Vallet、Robert N. Muller

  DOI：10.1016/s0040-4020(01)81211-4

  日期：1994.1

  The synthesis of new but unstable alpha-(hydroxymethyl)oxazolidin-3-oxyls was achieved after protection by silylation of the hydroxyl groups in order to avoid decomposition in diamagnetic nitrones. Relaxivity studies of (R,S)-4-(hydroxymethyl)-2,2,4-trimethyloxazolidin-3-oxyl 1 show no beneficial effect due to the presence of an hydroxymethyl group in the vicinity of the N-O group on the paramagnetic properties of nitroxides.