(4-Nitrophenyl)methyl 3-(azidomethyl)-6-bromo-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4-Nitrophenyl)methyl 3-(azidomethyl)-6-bromo-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• 英文别名: (4-nitrophenyl)methyl 3-(azidomethyl)-6-bromo-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• 化学式: C15H14BrN5O5S
• 分子量: 456.3
• InChiKey: HSXZCWQYFVCDIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  132
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Process for preparation of penam derivatives
  申请人：Gego Lehel Csaba

  公开号：US20060173177A1

  公开（公告）日：2006-08-03

  The invention relates to novel processes for preparing penam derivatives, such as Tazobactam and derivatives thereof. The processes according to the invention encompass procedures for the protection and deprotection of the carboxylic group as well as for the oxidation of the sulfur moiety of penam derivatives. Additionally, the present invention relates to new intermediates for the production of penam derivatives, allowing the desired penam-derivatives to be formulated with high purity and in good yields.

  该发明涉及制备革兰氏阴道的新型过程，如他唑巴坦及其衍生物。根据该发明的过程涵盖了对革兰氏阴道羧基的保护和去保护程序，以及对革兰氏阴道硫基的氧化。此外，本发明涉及用于制备革兰氏阴道的新中间体，使得所需的革兰氏阴道衍生物能够以高纯度和良好产率进行配制。