(2S)-3-[4-[bis(2-chloroethyl)amino]phenyl]-2-(butan-2-yloxycarbonylamino)propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-3-[4-[bis(2-chloroethyl)amino]phenyl]-2-(butan-2-yloxycarbonylamino)propanoic acid
• 化学式: C₁₈H₂₆Cl₂N₂O₄
• 分子量: 405.3
• InChiKey: IZIDSKSMONWDFQ-VYIIXAMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Bioorthogonal compositions
  申请人：TAMBO, INC.

  公开号：US11253600B2

  公开（公告）日：2022-02-22

  Cyclooctene conjugates of therapeutic or diagnostic agents have improved aqueous solubility and can release the agents upon contact with a tetrazine-containing biomaterial. The cyclooctene conjugates provide site-selective delivery of agents at the location of the tetrazine-containing biomaterial in a subject. The compositions and methods have applications in the treatment of various diseases or conditions including cancer, tumor growths, and bacterial infections.

  治疗剂或诊断剂的环辛烯共轭物具有更好的水溶性，并能在与含四嗪生物材料接触时释放药剂。环辛烯共轭物可在受试者体内含四氮生物材料的位置选择性地给药。这些组合物和方法可用于治疗各种疾病或病症，包括癌症、肿瘤生长和细菌感染。
• BIOORTHOGONAL COMPOSITIONS
  申请人：TAMBO, INC.

  公开号：US20210128733A1

  公开（公告）日：2021-05-06

  Cyclooctene conjugates of therapeutic or diagnostic agents have improved aqueous solubility and can release the agents upon contact with a tetrazine-containing biomaterial. The cyclooctene conjugates provide site-selective delivery of agents at the location of the tetrazine-containing biomaterial in a subject. The compositions and methods have applications in the treatment of various diseases or conditions including cancer, tumor growths, and bacterial infections.