4-(Cycloocten-1-yl)-5,6,7,8,9,9a-hexahydrocycloocta[c]furan-1,3-dione

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-(Cycloocten-1-yl)-5,6,7,8,9,9a-hexahydrocycloocta[c]furan-1,3-dione
• 英文别名: 4-(cycloocten-1-yl)-5,6,7,8,9,9a-hexahydrocycloocta[c]furan-1,3-dione
• 化学式: C₁₈H₂₄O₃
• 分子量: 288.4
• InChiKey: BYLQNTLIUUTHHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Solubilization and Targeted Delivery of Drugs With Self-Assembling Amphiphilic Polymers
  申请人：Diwan Anil

  公开号：US20100260743A1

  公开（公告）日：2010-10-14

  There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors that are capable of solubilizing insoluble organic compounds such as drugs, vitamins, dyes, and imaging agents. The polymers optionally feature reactive functional groups that provide attachment points for antibodies, ligands, and other targeting moieties useful for the targeted delivery of drugs and imaging agents.

  提供的两性可降解共聚物包括具有羟基亲水骨架和作为疏水组分的脂肪族侧链的共聚物。这些聚合物在水性环境中形成纳米级分子聚集体，具有疏水内部，能够溶解不溶于水的有机化合物，如药物、维生素、染料和成像剂。这些聚合物可选择性地具有反应性功能基团，提供与抗体、配体和其他靶向基团的结合点，有助于药物和成像剂的靶向传递。
• SELF ASSEMBLING AMPHIPHILIC POLYMERS AS ANTIVIRAL AGENTS
  申请人：Diwan Anil

  公开号：US20100008938A1

  公开（公告）日：2010-01-14

  There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors that are capable of solubilizing insoluble organic compounds and disrupting viral coat proteins. The polymers optionally feature reactive functional groups that provide attachment points for antibodies, ligands, and other targeting moieties which mediate adherence of the aggregate to a viral target.

  提供的两性亲水可生物降解共聚物包括具有侧链脂肪族基作为疏水成分的亲水性骨架。这些聚合物在水性环境中形成纳米级分子聚集体，具有疏水内部，能够溶解不溶性有机化合物并破坏病毒外壳蛋白。这些聚合物可选择性地具有反应性功能基团，提供抗体、配基和其他靶向基团的附着点，介导聚集体与病毒靶标的粘附。
• SELF-ASSEMBLING AMPHIPHILIC POLYMERS AS ANTI-CANCER AGENTS
  申请人：Diwan Anil R.

  公开号：US20100239659A1

  公开（公告）日：2010-09-23

  The invention provides amphiphilic biocompatible copolymers which have a hydrophilic backbone and pendant hydrophobic groups. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors within which anticancer drugs may be solubilized. The polymers optionally feature attached antibodies, receptor ligands, and other targeting moieties which mediate adherence of the drug-carrying aggregates to targeted cancer cells.

  本发明提供了一种两性亲水的生物相容性共聚物，其具有亲水性骨架和挂链疏水基团。这些聚合物在水性环境中形成纳米级分子聚集体，其中具有疏水性内部，可在其中溶解抗癌药物。这些聚合物可选地具有连接的抗体、受体配体和其他靶向基团，这些基团介导药物携带聚集体与靶向癌细胞的附着。
• Polymers made from triazine derivatives
  申请人：Agrolinz Melamin GmbH

  公开号：US20030045667A1

  公开（公告）日：2003-03-06

  Polymers made from triazine derivatives for intermediates and molded materials with improved toughness and high flame resistance and strength consisting of A) 60 to 95 percent by weight of triazine derivative mixtures consisting of A1) 20 to 70 percent by weight of triazine derivatives with hydroxyalkyl amino groups A2) 80 to 30 percent by weight of triazine derivatives with bis(hydroxyalkyl) imino groups B) 5 to 40 percent by weight of polyfunctional compounds consisting of B1) polyfunctional isocyanates and/or oligomeric polyesters or polyethers with isocyanate end groups or B2) aliphatic and/or aromatic polybasic carboxylic acids, carboxylic esters, carboxylic acid chlorides or carboxylic acid anhydrides, or B3) aliphatic or aromatic di- and/or triglycidyl compounds, and, optionally, of C) 1 to 20 percent by weight of other functional compounds consisting of C1) aliphatic and/or aromatic dihydroxy compounds, and/or C2) polyalkylene glycols with a molar weight in the range from 200 to 6000, and/or C3) C 1 -C 8 aliphatic aldehydes are produced in a melt process in continuous kneaders at 160 to 280° C. or in a stirred tank reactor process at 50 to 150° C. and pressures of 1 to 15 bar. The polymers made from triazine derivatives are suited for producing uncured or cross-linked compression molded or injection molded products, films, fibers, pipes, plates and hollow bodies, microcapsules, foams, coatings, laminates, or impregnated flat-shaped carrier materials.

  由三嗪衍生物制成的聚合物，用于中间体和模塑材料，具有更好的韧性、高阻燃性和高强度，其成分包括 A) 60%至 95%（按重量计）的三嗪衍生物混合物，包括 A1) 20%至 70%（重量百分比）带有羟基烷基氨基的三嗪衍生物 A2) 80%至 30%（重量百分比）带有双（羟烷基）亚氨基基团的三嗪衍生物 B) 5%至 40%（重量百分比）的多官能团化合物，包括 B1) 多官能异氰酸酯和/或带有异氰酸酯端基的低聚聚酯或聚醚，或 B2) 脂肪族和/或芳香族多基质羧酸、羧酸酯、羧酸氯化物或羧酸酸酐，或 B3) 脂肪族或芳香族二和/或三缩水甘油酯化合物，以及可选的以下物质 C)重量百分比为 1%至 20%的其他功能化合物，包括 C1) 脂肪族和/或芳香族二羟基化合物，和/或 C2) 摩尔重量在 200-6000 之间的聚亚烷基二醇，和/或 C3) C 1 -C 8 或 C3）C 1 -C 8 脂肪醛，在连续捏合机中以熔融法生产，温度为 160 至 280 摄氏度，或在搅拌罐反应器中以 50 至 150 摄氏度和 1 至 15 巴的压力生产。由三嗪衍生物制成的聚合物适用于生产未固化或交联的压缩模塑或注射模塑产品、薄膜、纤维、管道、板材和空心体、微胶囊、泡沫、涂层、层压板或浸渍扁平载体材料。
• SOLUBILIZATION AND TARGETED DELIVERY OF DRUGS WITH SELF-ASSEMBLING AMPHIPHILIC POLYMERS
  申请人：Allexcel, Inc.

  公开号：EP1979407A1

  公开（公告）日：2008-10-15