3-Azido-2-hydroxy-1-morpholin-4-ylpropan-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 3-Azido-2-hydroxy-1-morpholin-4-ylpropan-1-one
• 英文别名: 3-azido-2-hydroxy-1-morpholin-4-ylpropan-1-one
• 化学式: C7H12N4O3
• 分子量: 200.2
• InChiKey: BAQGOQXTZVCHNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Enhanced indolinone based protein kinase inhibitors
  申请人：Liang Congxin

  公开号：US20060287381A1

  公开（公告）日：2006-12-21

  Hydroxy carboxy pyrrolyl-indolinone derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer. More particularly, alpha-hydroxy-omega-(2-oxo-indolylidenemethyl-pyrrole-3′-carbonyl) amino alkanoic acid and amide derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases with respect to their corresponding beta-hydroxy-omega-(2-oxo-indolylidenemethyl-pyrrole-3′-carbonyl) amino alkanoic acid and amide derivatives and are useful in treating disorders related to abnormal protein kinase activities such as cancer.

  羟基羧基吡咯基吲哚酮衍生物具有增强和意外的药物特性，可以作为蛋白激酶抑制剂，用于治疗与异常蛋白激酶活性相关的疾病，如癌症。特别地，α-羟基-ω-（2-氧代吲哚亚甲基吡咯-3'-羧酰基）氨基脂肪酸和酰胺衍生物具有增强和意外的药物特性，可作为蛋白激酶抑制剂，相对于其相应的β-羟基-ω-（2-氧代吲哚亚甲基吡咯-3'-羧酰基）氨基脂肪酸和酰胺衍生物，用于治疗与异常蛋白激酶活性相关的疾病，如癌症。
• Enhanced Indolinone Based Protein Kinase Inhibitors
  申请人：Liang Congxin

  公开号：US20100267719A1

  公开（公告）日：2010-10-21

  Alpha-hydroxy-omega-(2-oxo-indolylidenemethyl-pyrrole-3′-carbonyl)amino alkanoic acid and amide derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.

  Alpha-hydroxy-omega-(2-oxo-indolylidenemethyl-pyrrole-3′-carbonyl)amino烷基酸和酰胺衍生物具有增强和意外的药物特性，可作为蛋白激酶抑制剂用于治疗与异常蛋白激酶活性相关的疾病，如癌症。
• ENHANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：EP1893194A1

  公开（公告）日：2008-03-05
• EP1893194A4
  申请人：——

  公开号：EP1893194A4

  公开（公告）日：2009-07-01
• [EN] ENHANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS<br/>[FR] INHIBITEURS DE LA PROTEINE KINASE A BASE D'INDOLINONE AMELIOREE
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2006127961A1

  公开（公告）日：2006-11-30

  [EN] Alpha-hydroxy- omega-(2-oxo-indolylidenemethyl-pyrrole-3'-carbonyl) amino alkanoic acid and amide derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
  [FR] Selon l'invention, un acide alpha-hydroxy-oméga-(2-oxo-indolylideneméthyl-pyrrole-3'-carbonyl) amino alcanoïque et des dérivés amide présentent des propriétés médicamenteuses améliorées et inattendues en tant qu'inhibiteurs des protéines kinases et conviennent au traitement de troubles relatifs à des activités anormales de la protéine kinase, tels que le cancer.