(10R,12S)-10,12-dimethyltetradecanal

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (10R,12S)-10,12-dimethyltetradecanal
• 化学式: C₁₆H₃₂O
• 分子量: 240.42
• InChiKey: AXKHRSCHRJLHSG-JKSUJKDBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF FUNGAL INFECTIONS<br/>[FR] COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT D'INFECTIONS FONGIQUES
  申请人：CIDARA THERAPEUTICS INC

  公开号：WO2015035102A2

  公开（公告）日：2015-03-12

  Compositions and methods for the treatment of fungal infections including compounds containing a pathogen pattern recognition receptor ligand and a β 1,3-glucan synthase inhibitor are disclosed. In particular, compounds containing a lipopeptide moiety and a formyl peptide receptor ligand can be used in the treatment of fungal infections caused by a fungus of the genus Aspergillus or Candida.
• [EN] METHODS FOR PREVENTING AND TREATING PNEUMOCYSTIS INFECTIONS<br/>[FR] PROCÉDÉS DE PRÉVENTION ET DE TRAITEMENT D'INFECTIONS À PNEUMOCYSTIS
  申请人：CIDARA THERAPEUTICS INC

  公开号：WO2017120471A1

  公开（公告）日：2017-07-13

  The disclosure relates to methods of prophylactic and therapeutic treatments of a Pneumocystis infection (i.e., an infection caused by Pneumocystis jirovecii) in a subject by administering to the subject a compound of any of formulas (l)-(lll) (e.g., a salt of Compound 1, or a neutral form thereof). The disclosure also relates to methods of inhibiting the replication of a Pneumocystis spp. The methods of the disclosure can be useful in immunocompromised subjects.