10,10-Dimethylundecan-1-ol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 10,10-Dimethylundecan-1-ol
• 英文别名: 10,10-dimethylundecan-1-ol
• 化学式: C₁₃H₂₈O
• 分子量: 200.36
• InChiKey: NVRRUKJGVIPBEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• TRITERPENE SAPONINS, METHODS OF SYNTHESIS AND USES THEREOF
  申请人：MEMORIAL SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH

  公开号：US20150086585A1

  公开（公告）日：2015-03-26

  The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.

  本发明涉及以三萜甙苷皂苷为基础的佐剂，其合成，中间体以及使用方法。 QS-7是一种强效的免疫佐剂，其毒性明显低于QS-21，QS-21是当前抗癌和抗病毒疫苗中受欢迎的佐剂。繁琐的分离和纯化协议阻碍了QS-7的临床开发。提供了一种新的半合成方法，其中使用水解的原皂苷混合物来合成QS-7，QS-21和相关类似物，极大地促进了QS-7和QS-21类似物的临床前和临床评估。
• QUANTUM DOT-CONTAINING COMPLEX, AND LIGHT-EMITTING DEVICE, OPTICAL MEMBER, AND DEVICE, EACH INCLUDING THE SAME
  申请人：Samsung Display Co., Ltd.

  公开号：EP3816262A1

  公开（公告）日：2021-05-05

  A quantum dot-containing complex that may be used in a light emitting device, an optical member or devices including same includes: a quantum dot; and at least one ligand coordinated to the surface of the quantum dot and being a monomer represented by Formula 1, as defined herein.

  一种可用于发光器件、光学部件或包括发光器件、光学部件或包括光学部件的器件的含量子点复合物包括：量子点；以及至少一种配位到量子点表面且由式 1 所代表的单体（如本文所定义）。
• US9718850B2
  申请人：——

  公开号：US9718850B2

  公开（公告）日：2017-08-01