S-[(R)-2-(1-iminoethylamino)propyl]-D-cysteine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: S-[(R)-2-(1-iminoethylamino)propyl]-D-cysteine
• 英文别名: (2S)-2-[[(2R)-2-(1-aminoethylideneamino)propyl]amino]-3-sulfanylpropanoic acid
• 化学式: C₈H₁₇N₃O₂S
• 分子量: 219.308
• InChiKey: KVDAEMZAZFBWSW-IYSWYEEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  88.7
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• IN VITRO METHOD FOR IDENTIFYING THORACIC AORTIC ANEURYSMS (TAA) IN A SUBJECT
  申请人：Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)

  公开号：EP3427061A1

  公开（公告）日：2019-01-16
• [EN] IN VITRO METHOD FOR IDENTIFYING THORACIC AORTIC ANEURYSMS (TAA) IN A SUBJECT<br/>[FR] PROCÉDÉ IN VITRO D'IDENTIFICATION D'ANÉVRISMES DE L'AORTE THORACIQUE (AAT) CHEZ UN SUJET
  申请人：CNIC FUNDACIÓN CENTRO NAC DE INVESTIG CARDIOVASCULARES CARLOS III

  公开号：WO2017153023A1

  公开（公告）日：2017-09-14

  The present invention refers to an In vitro method for screening for subjects at risk of developing thoracic aortic aneurysm (TAA) or a disease causing TAA comprising: (a) measuring the expression pattern or level of at least A Disintegrin And Metalloproteinase with Thrombospondin Motifs 1 (ADAMTS1) obtained from an isolated biological sample of the subjects to be screened; and (b) comparing said expression pattern or level of at least ADAMTS1 of the subjects to be screened with an already established expression pattern or level, wherein reduced expression of at least ADAMTS1 is indicative of a thoracic aortic aneurysm (TAA).