1-Amino-1-azidoundecane-3,6,9-trione

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 1-Amino-1-azidoundecane-3,6,9-trione
• 英文别名: 1-amino-1-azidoundecane-3,6,9-trione
• 化学式: C11H18N4O3
• 分子量: 254.29
• InChiKey: DMJKNIHBJQFRIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  91.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] TETHERED ACTIVITY-BASED PROBES AND USES THEREOF<br/>[FR] SONDES CAPTIVES LIEES A UNE ACTIVITE ET LEURS APPLICATIONS
  申请人：ACTIVX BIOSCIENCES INC

  公开号：WO2003079014A1

  公开（公告）日：2003-09-25

  Methods and compositions are described for analyzing complex protein mixtures, such as proteomes, using activity-based probes. In particular, probes that specifically react with and bind to the active form of one or more target proteins are employed. Labeled proteins and/or peptides can be sequestered using a tABP covalently bound (“tethered”) to a solid phase, and, upon cleavage of the tether, can be related to the identity, presence, amount, or activity of active members of the desired target protein class. The methods and compositions described herein can be used, for example, to provide diagnostic information concerning pathogenic states, in identifying proteins that may act as therapeutic targets, and in drug discovery.