(3r)-6,7-Bis(hydroxymethyl)-1h,3h-pyrrolo[1,2-c]thiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: (3r)-6,7-Bis(hydroxymethyl)-1h,3h-pyrrolo[1,2-c]thiazole
• 英文别名: [7-(hydroxymethyl)-1,3-dihydropyrrolo[1,2-c][1,3]thiazol-6-yl]methanol
• 化学式: C₈H₁₁NO₂S
• 分子量: 185.25
• InChiKey: CJEOPXONBRFWHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] "(3S)- AND (3R)-6,7-BIS(HYDROXYMETHYL)-1H,3H-PYRROLO[1,2-C]THIAZOLES AS P53 ACTIVATORS"<br/>[FR] (3S)- ET (3R)-6,7-BIS (HYDROXYMÉTHYL)-1H,3H-PYRROLO[1,2-C]THIAZOLES UTILISÉS COMME ACTIVATEURS DE P53
  申请人：UNIV DE COIMBRA

  公开号：WO2019243906A1

  公开（公告）日：2019-12-26

  The present application relates to compounds of formula I, which are (3S)- and (3R)-6,7-bis(Hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles. The present application also relates to pharmaceutical compositions comprising said compounds and the use of these compounds in the treatment of conditions influenced by wild-type or mutant p53 forms. More specifically, these compounds represent a completely new chemical family of p53-activating agents and show a higher selectivity towards the p53-pathway compared to the reactivators of p53 currently under clinical trials. For some cancer types these compounds revealed to be more potent than the reactivators of p53 currently under clinical trials. In addition to these advantages, the presently disclosed compounds are not genotoxic and have no apparent undesirable toxic side effects.

  本申请涉及的化合物属于公式I，即(3S)-和(3R)-6,7-双(羟甲基)-1H,3H-吡咯并[1,2-c]噻唑。本申请还涉及包含上述化合物的药物组合物，以及这些化合物在治疗受野生型或突变型p53形式影响的疾病中的用途。更具体地说，这些化合物代表了一种全新的p53激活剂化学家族，并显示出与目前正在临床试验中的p53再活化剂相比更高的选择性作用于p53途径。对于某些癌症类型，这些化合物显示出比目前正在临床试验中的p53再活化剂更强效的作用。除了这些优势外，目前披露的化合物不具有基因毒性，并且没有明显的不良毒性副作用。
• ANTI-CANCER AZOLE COMPOUNDS
  申请人：Imam Abdulrahman Bin Faisal University

  公开号：US20200375952A1

  公开（公告）日：2020-12-03

  Compounds comprising azole moieties are disclosed. The disclosed compounds are shown to have anticancer activity. Also disclosed are pharmaceutical composition of the compounds and method of their use in the treatment of cancer.

  本发明揭示了由唑类基团组成的化合物。所揭示的化合物具有抗癌活性。本发明还揭示了该化合物的药物组合物以及在癌症治疗中使用的方法。
• Anti-cancer azole compounds
  申请人：Imam Abdulrahman Bin Faisal University

  公开号：US10918624B2

  公开（公告）日：2021-02-16

  Compounds comprising azole moieties are disclosed. The disclosed compounds are shown to have anticancer activity. Also disclosed are pharmaceutical composition of the compounds and method of their use in the treatment of cancer.

  本研究公开了包含唑基的化合物。所公开的化合物具有抗癌活性。还公开了这些化合物的药物组合物及其用于治疗癌症的方法。
• (3S)- AND (3R)-6,7-BIS(HYDROXYMETHYL)-1H,3H-PYRROLO[1,2-C]THIAZOLES AS P53 ACTIVATORS
  申请人：Universidade de Coimbra

  公开号：EP3810278A1

  公开（公告）日：2021-04-28