ZINC histidinate | 144071-79-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ZINC histidinate
• 英文别名: zinc;2-amino-3-(1H-imidazol-5-yl)propanoate
• CAS: 144071-79-4
• 化学式: C12H16N6O4Zn
• 分子量: 373.7
• InChiKey: BRKFIPNBXFDCDM-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.94
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  190
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Multifunction "Crown Complexes" from Amino Acids and Peptides for Skin and Hair Restoration
  申请人：Gupta K Shyam

  公开号：US20070099886A1

  公开（公告）日：2007-05-03

  This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2 . The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.

  本发明涉及从氨基酸和羟基芳基烷基酮衍生的席夫碱，或含有该类化合物的植物提取物，其具有图1中的一般化学结构，用于局部应用。本发明还涉及所述席夫碱的某些金属配合物，其在三维化学结构中呈冠状外观，如图2所示。本发明的席夫碱及其金属配合物对于调节金属活化酶和金属酶，例如苯丙氨酸羟化酶、酪氨酸转氨酶、苯丙氨酸转氨酶、酪氨酸酶、各种基质金属蛋白酶、超氧化物歧化酶、5α-还原酶和柠檬酸裂解酶具有用途。此外，它们还适用于多功能局部方法，如美白肌肤、减少皮肤皱纹、抗衰老、胶原蛋白合成、控制痤疮、预防脱发、控制白发和面部油脂控制。
• Hair Loss Prevention by Natural Amino Acid and Peptide Complexes
  申请人：GUPTA SHYAM K

  公开号：US20090253668A1

  公开（公告）日：2009-10-08

  This invention relates to certain skin and hair care agents of formula (I), derived from natural amino acids and peptides. These agents provide multi-functional treatment of enzyme-related skin, hair and scalp problems, for example, hair aging including premature hair loss and hair graying; male pattern baldness; hair loss from dandruff; alopecia; split ends, acne, darkened skin, dark circles around eyes, stretch marks, wrinkles and fine lines, loss of collagen, loss of skin pliability and combinations thereof:

  本发明涉及公式（I）的某些皮肤和头发护理剂，这些护理剂源自天然氨基酸和肽。这些护理剂提供多功能的酶相关皮肤、头发和头皮问题的治疗，例如，头发老化，包括过早脱发和白发；男性型脱发；头皮屑引起的脱发；脱发斑秃；分叉，痤疮，皮肤变黑，眼周黑眼圈，妊娠纹，皱纹和细纹，胶原蛋白流失，皮肤柔韧性流失和它们的组合：
• Skin and Hair Restoration by Natural Amino Acid and Peptide Crown Complexes
  申请人：GUPTA SHYAM K.

  公开号：US20080287536A1

  公开（公告）日：2008-11-20

  This invention relates to certain skin and hair care agents of formula (I), derived from natural amino acids and peptides. These agents provide multi-functional treatment of enzyme-related topical problems, for example, darkened skin including age spots, circles around eyes and stretch marks; skin conditions related to acne including excess facial oil and facial pore size; premature hair aging including hair loss and graying; inflammation including intra-cellular and extra-cellular inflammation; skin aging including wrinkles and fine lines; loss of collagen including thinning skin and loss of skin pliability; malfunction of tyrosinase group of enzymes; malfunction of matrix metalloprotease group of enzymes; and combinations thereof: Wherein, R, R′, and R″=any substituent(s); and M=H, Li, Na, K, Ca, Mg, Zn, Mn, Cu, Fe, Co, Mo, V, Cr, Ammonium, Alkyl ammonium, and Nitrogen Heterocyclic ammonium.

  本发明涉及一种公式（I）的天然氨基酸和肽衍生的某些皮肤和头发护理剂。这些剂提供了多功能的酶相关局部问题治疗，例如黑色皮肤，包括老年斑，眼周圆圈和妊娠纹; 与痤疮相关的皮肤状况，包括过多的面部油脂和面部毛孔大小; 早期头发老化，包括脱发和变白; 炎症，包括细胞内和细胞外炎症; 皮肤老化，包括皱纹和细纹; 胶原蛋白丢失，包括皮肤变薄和失去弹性; 酪氨酸酶类酶的功能障碍; 基质金属蛋白酶酶类的功能障碍; 以及它们的组合：其中，R，R'和R'' = 任何取代基; M = H，Li，Na，K，Ca，Mg，Zn，Mn，Cu，Fe，Co，Mo，V，Cr，铵，烷基铵和氮杂环铵。
• Fast acting inhibitor of gastric acid secretion
  申请人：YALE UNIVERSITY

  公开号：US10278989B2

  公开（公告）日：2019-05-07

  The present invention relates to the use of pharmaceutically acceptable zinc salts, in particular, zinc chloride and zinc acetate, alone or optionally, in combinations with one or more of a protein pump inhibitor (PPI), H2 blocker, anti-H. pylori antibiotic/antimicrobial, cytoprotective agent or a combination agent as otherwise described herein for providing fast action with optional long duration effect in reducing gastric acid secretion, including acid secretion in the fundus (by inhibiting vacuolar H+-ATPase or H+/K+-ATPase) and upper body region of the stomach (by inhibiting H+/K+-ATPase), thus raising the pH of gastric juices in rapid fashion and decreasing the duration of stomach acid release during a secretagogue phase. This method is also directed to treating conditions including gastroesophageal reflux disease (GERD), non-erosive reflux disease (NERD), Zollinger-Ellison syndrome (ZE disease), ulcer disease, and gastric cancer, as well as preventing or reducing the likelihood of ulcer disease. In addition, the present methods are useful for treating patients who are non-responsive to proton pump inhibitors (PPI) and as an alternative to traditional therapies or conditions which are caused by rapid and complete inhibition of secretagogue induced acid secretion.

  本发明涉及药学上可接受的锌盐，特别是氯化锌和醋酸锌，单独或与一种或多种蛋白泵抑制剂（PPI）、H2 受体阻滞剂、抗幽门螺杆菌抗生素/抗菌剂、细胞保护剂或本文所述的复方制剂组合使用，以提供快速作用和可选的长效作用，减少胃酸分泌，包括胃酸在胃中的分泌。特别是氯化锌和醋酸锌，单独使用或与一种或多种蛋白泵抑制剂（PPI）、H2 受体阻滞剂、抗幽门螺杆菌抗生素/抗菌剂、细胞保护剂或本文另外描述的复方制剂联合使用，可在减少胃酸分泌，包括胃底（通过抑制空泡 H+-ATP 酶或 H+/K+-ATP 酶）和胃上部（通过抑制 H+/K+-ATP 酶）的胃酸分泌方面提供快速作用和可选的长效作用，从而快速提高胃液的 pH 值，减少分泌期胃酸释放的持续时间。本方法还可用于治疗胃食管反流病（GERD）、非胃食管反流病（NERD）、卓-艾综合征（ZE 病）、溃疡病和胃癌等疾病，以及预防或降低溃疡病的可能性。此外，本方法还可用于治疗对质子泵抑制剂（PPI）无反应的患者，并可替代传统疗法或因快速、完全抑制分泌物诱导的酸分泌而导致的病症。
• Dietary supplementation to achieve oxy-redox homeostasis and epigenetic stability
  申请人：PARTHENOGEN SAGL

  公开号：US10966949B2

  公开（公告）日：2021-04-06

  The invention describes pharmaceutical, dietary and/or food compositions, preferably dietary supplements, exerting the ability to activate the endogenous antioxidant system by feeding essential micronutrients to both the one carbon cycle and the trans-sulfuration pathway so to achieve effective oxy-redox homeostasis together with an improved energy balance and healthy processes of cell growth and differentiation including DNA methylation and epigenetic regulation. The invention further relates to the use of the aforementioned compositions to decrease homocysteine levels and for the support to menopause, pregnancy and reproductive competence and for the prevention and/or treatment of diabetes, celiac disease, neurodegenerative diseases, cardiovascular diseases, Autism Spectrum Disorders (ASD) or Neurodevelopmental Disorders.

  本发明描述了药物、膳食和/或食品组合物，最好是膳食补充剂，通过向一碳循环和反式硫化途径提供必需的微量营养素，发挥激活内源性抗氧化系统的能力，从而实现有效的氧化还原平衡，同时改善能量平衡和健康的细胞生长和分化过程，包括 DNA 甲基化和表观遗传调节。 本发明进一步涉及使用上述组合物来降低同型半胱氨酸水平，支持更年期、妊娠和生殖能力，预防和/或治疗糖尿病、乳糜泻、神经退行性疾病、心血管疾病、自闭症谱系障碍（ASD）或神经发育障碍。