L-Arginine alpha-Ketoglutarate(1:1)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Arginine alpha-Ketoglutarate(1:1)
• 英文别名: 2-amino-5-(diaminomethylideneamino)pentanoic acid;2-oxopentanedioic acid
• 化学式: C11H20N4O7
• 分子量: 320.3
• InChiKey: PGRNZHOQVAPMFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.04
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  219
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• [EN] METHODS AND COMPOSITIONS INVOLVING (S)-BUCINDOLOL<br/>[FR] MÉTHODES ET COMPOSITIONS METTANT EN JEU DU (S)-BUCINDOLOL
  申请人：ARCA DISCOVERY INC

  公开号：WO2010014263A1

  公开（公告）日：2010-02-04

  Disclosed is bucindolol substantially free of its R-stereoisomer. Also disclosed are pharmaceutical compositions that include bucindolol substantially free of its R-stereoisomer or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. Also disclosed are methods of treating a patient that involve administering to the patient a therapeutically effective amount of a composition of the present invention. Formula (I).

  本发明公开了几乎不含其R-立体异构体的布辛多洛。还公开了包括几乎不含其R-立体异构体或其药学上可接受的盐以及药学上可接受的载体的布辛多洛制剂。还公开了治疗患者的方法，该方法涉及向患者投与本发明组合物的治疗有效量。公式（I）。
• COMPOSITIONS COMPRISING UNSATURATED FATTY ACIDS AND NITRIC OXIDE RELEASING COMPOUNDS AND USE THEREOF FOR ENHANCING COGNITIVE AND RELATED FUNCTIONS
  申请人：Nestec S.A.

  公开号：EP3058942A1

  公开（公告）日：2016-08-24

  Compositions comprising one or more unsaturated fatty acids and one or more nitric oxide releasing compounds, and methods for using such compositions for enhancing cognitive function, reducing or preventing a decline of social interaction, reducing or preventing age-related behavioral changes, increasing trainability, maintaining optimal brain function, facilitating learning and memory, reducing memory loss, retarding brain aging, preventing or treating strokes, and preventing or treating dementia in an animal Preferably, the compositions are food compositions useful for enhancing cognitive function in humans and companion animals.

  由一种或多种不饱和脂肪酸和一种或多种一氧化氮释放化合物组成的组合物，以及使用这种组合物增强认知功能、减少或防止社会交往能力下降、减少或防止与年龄相关的行为变化、提高可训练性、保持最佳脑功能、促进学习和记忆、减少记忆丧失、延缓脑衰老、预防或治疗中风、预防或治疗动物痴呆症的方法 优选地，这些组合物是有助于增强人类和伴侣动物认知功能的食品组合物。
• PERFORMANCE ENHANCING COMPOSITION
  申请人：HeartBeet Ltd.

  公开号：EP3159000A1

  公开（公告）日：2017-04-26

  The performance of a mammal, manifested as a reduced oxygen uptake (VO2) during physical exercise, can be enhanced by administering to said mammal a non-toxic amount of nitrate and/or nitrite. Liquid, semi-solid and solid snack and food products and nutritional supplements, such as sport drinks are made available.

  通过向哺乳动物施用无毒量的硝酸盐和/或亚硝酸盐，可以提高哺乳动物的运动表现，表现为运动期间摄氧量（VO2）的降低。可提供液体、半固体和固体零食和食品以及营养补充剂，如运动饮料。
• Compositions and methods useful for ameliorating age related maladies
  申请人：Satyaraj Ebenezer

  公开号：US10010566B2

  公开（公告）日：2018-07-03

  The invention provides methods and compositions useful for ameliorating age related maladies, enhancing and maintaining immune function, enhancing and maintaining cognitive function, enhancing and maintaining muscle strength, enhancing and maintaining balance, and reducing and mitigating oxidative stress in an animal. The compositions comprise a combination of at least two of one or more unsaturated fatty acids (UFA); one or more nitric oxide releasing compounds (NORC); one or more anti-glycation agents; and colostrum, and the methods comprise administering to an animal a therapeutically effective amount of the compositions.

  本发明提供的方法和组合物有助于改善与年龄有关的弊病，增强和维持免疫功能，增强和维持认知功能，增强和维持肌肉力量，增强和维持平衡，以及减少和减轻动物的氧化应激。组合物包括一种或多种不饱和脂肪酸（UFA）中至少两种的组合；一种或多种一氧化氮释放化合物（NORC）；一种或多种抗糖化剂；以及牛初乳，方法包括向动物施用治疗有效量的组合物。
• Compositions comprising unsaturated fatty acids and nitric oxide releasing compounds and use thereof for enhancing cognitive and related functions
  申请人：NESTEC S.A.

  公开号：US10111911B2

  公开（公告）日：2018-10-30

  Compositions include one or more unsaturated fatty acids and one or more nitric oxide releasing compounds. Methods for using such compositions can enhance cognitive function, reduce or prevent a decline of social interaction, reduce or prevent age-related behavioral changes, increase trainability, maintain optimal brain function, facilitate learning and memory, reduce memory loss, retard brain aging, prevent or treat strokes, and/or prevent or treat dementia in an animal. Preferably, the compositions are food compositions useful for enhancing cognitive function in humans and companion animals.

  组合物包括一种或多种不饱和脂肪酸和一种或多种一氧化氮释放化合物。使用这种组合物的方法可以增强动物的认知功能，减少或防止社会交往能力下降，减少或防止与年龄相关的行为变化，提高可训练性，保持最佳脑功能，促进学习和记忆，减少记忆丧失，延缓大脑衰老，预防或治疗中风，和/或预防或治疗痴呆症。优选地，这些组合物是有助于增强人类和伴侣动物认知功能的食品组合物。