(3,6-diethyl-5-methylpyrazin-2-yl)methanol | 1609379-41-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (3,6-diethyl-5-methylpyrazin-2-yl)methanol
• 英文别名: 2-hydroxymethyl-3,6-diethyl-5-methylpyrazine；2-Hydroxymethyl-3,6-diethyl-5-methylpyrazine
• CAS: 1609379-41-0
• 化学式: C₁₀H₁₆N₂O
• 分子量: 180.25
• InChiKey: TUJCXJYDEUXBPG-UHFFFAOYSA-N

物化性质

• 沸点：
  272.8±35.0 °C(Predicted)
• 密度：
  1.050±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  46
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,5-二乙基-3,6-二甲基吡嗪 在 双氧水 、 溶剂黄146 、 lithium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 34.5h， 生成 (3,6-diethyl-5-methylpyrazin-2-yl)methanol
  参考文献：
  名称：

  Alkylations and Hydroxymethylations of Pyrazines via Green Minisci-Type Reactions

  摘要：

  A new general methodology utilizing Minisci-type chemistry has been developed that cleanly and efficiently prepares alkyl- and (hydroxymethyl)pyrazines. The new methods eliminate toxic catalysts and halogenated solvents, providing a greatly improved route to these natural products which are prevalent in many natural systems as bacterial volatiles, plant volatiles, and insect pheromones.

  DOI：

  10.1021/ol500776j

文献信息

• Alkylations and Hydroxymethylations of Pyrazines via Green Minisci-Type Reactions
  作者：Bjorn Bohman、Benjamin Berntsson、Ruby C. M. Dixon、Craig D. Stewart、Russell A. Barrow

  DOI：10.1021/ol500776j

  日期：2014.6.6

  A new general methodology utilizing Minisci-type chemistry has been developed that cleanly and efficiently prepares alkyl- and (hydroxymethyl)pyrazines. The new methods eliminate toxic catalysts and halogenated solvents, providing a greatly improved route to these natural products which are prevalent in many natural systems as bacterial volatiles, plant volatiles, and insect pheromones.