[2,2-Dichloro-1-(4-methyl-benzoylamino)-vinyl]-phosphonic acid diethyl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2,2-Dichloro-1-(4-methyl-benzoylamino)-vinyl]-phosphonic acid diethyl ester
• 英文别名: (2,2-Dichloro-1-(4-methyl-benzoylamino)-vinyl)-phosphonic acid diethyl ester；N-(2,2-dichloro-1-diethoxyphosphorylethenyl)-4-methylbenzamide
• 化学式: C₁₄H₁₈Cl₂NO₄P
• mdl: MFCD00181796
• 分子量: 366.181
• InChiKey: WIORAUDKDZYFMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [2,2-Dichloro-1-(4-methyl-benzoylamino)-vinyl]-phosphonic acid diethyl ester 在 一水合肼 、 N,N-二甲基苯胺 作用下， 以 乙腈 为溶剂， 生成 N'-[4-diethoxyphosphoryl-2-(4-methylphenyl)-1,3-oxazol-5-yl]-2-oxochromene-3-carbohydrazide
  参考文献：
  名称：

  Synthesis of C-heteryl-substituted aminomethylphosphonic acids derivatives

  摘要：

  The available diethyl 5-hydrazino-2-p-tolyl-1,3-oxazol-1-ylphosphonate was readily acylated with chlorides of carboxylic acids of heterocyclic series. On heating in acetic acid it underwent the oxazole ring cleavage, recyclization and diethylation that was used to prepar the substituted 2-p-toluylaminomethylphosphonic acids containing a series of 2-heteryl-1,3,4-oxadiazol-5-yl residues in the alpha-position relative to the phosponyl group.

  DOI：

  10.1134/s1070363210040067

文献信息

• Reaction of diethyl 1-acylamino-2,2-dichloroethenylphosphonates with amino acids esters
  作者：K. M. Kondratyuk、E. I. Lukashuk、A. V. Golovchenko、E. B. Rusanov、V. S. Brovarets

  DOI：10.1134/s1070363212040056

  日期：2012.4

  Reactions of available diethyl 1-acylamino-2,2-dichloroethenylphosphonates with amino acids esters were studied, which in the case of esters of proline, nipecotic and isonipecotic acids resulted in N-substituted derivatives of 5-amino-4-diethoxyphosphoryloxazol in high yields. Their behavior in the acidic and alkaline media was investigated by the example of methyl N-(4-diethoxyphosphoryl-2-R-oxaz

  研究了可用的1-乙基氨基-2,2-二氯乙烯基膦酸二乙酯与氨基酸酯的反应，在脯氨酸，乳酸，异戊二烯酸酯的情况下，高产率地生成了5-氨基-4-二乙氧基磷酰基恶唑的N-取代衍生物。通过N-（4-二乙氧基磷酰基-2-R-恶唑-5-基）异癸二酸甲酯的实例研究了它们在酸性和碱性介质中的行为。
• Reaction of diethyl esters of 1-acylamino-2,2-dichlorovinylphosphonic acids and their analogs with the Lawesson’s reagent
  作者：S. V. Popil’nichenko、K. M. Kondratyuk、R. N. Solomyannyi、V. S. Brovarets

  DOI：10.1134/s1070363210100105

  日期：2010.10

  Diethyl esters of 1-acylamino-2,2-dichlorovinylphosphonic acids and their analogs upon heating with the Lawesson’s reagent are converted into the earlier unknown substituted 1,3-thiazol-4-ylthiophosphonates in high yields.

  将1-酰基氨基-2，2-二氯乙烯基膦酸的二乙酯及其类似物在与Lawesson试剂一起加热后，可以高产率转化为更早的未知取代的1,3-噻唑-4-基硫代膦酸酯。
• Lobanov, O. P.; Drach, B. S., Journal of general chemistry of the USSR, 1982, vol. 52, # 5, p. 980 - 988
  作者：Lobanov, O. P.、Drach, B. S.

  DOI：——

  日期：——
• Synthesis and some properties of 4-phosphorylated derivatives of 5-mercapto-1,3-oxazoles
  作者：K. M. Kondratyuk、E. I. Lukashuk、A. V. Golovchenko、A. N. Vasilenko、V. S. Brovarets

  DOI：10.1134/s1070363213010088

  日期：2013.1

  Various approaches to the synthesis of new derivatives of diethyl 5-mercapto-2-R-1,3-oxazole-4-ylphosphonates were considered. The behavior of these compounds in the presence of mineral acids and alkalis resulting in the synthesis of previously unknown 5-mercapto-2-R-1,3-oxazole-4-ylphosphonic acids was studied.
• LOBANOV, O. P.;DRACH, B. S., ZH. OBSHCH. XIMII, 1982, 52, N 5, 1122-1131
  作者：LOBANOV, O. P.、DRACH, B. S.

  DOI：——

  日期：——