2-(2-methylphenoxy)-N-(tricyclo[3.3.1.1~3,7~]dec-1-yl)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(2-methylphenoxy)-N-(tricyclo[3.3.1.1~3,7~]dec-1-yl)acetamide
• 英文别名: N-(1-adamantyl)-2-(2-methylphenoxy)acetamide
• 化学式: C₁₉H₂₅NO₂
• 分子量: 299.4
• InChiKey: RMWFBZRUWJDICZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• N-2 ADAMANTANYL-2-PHENOXY-ACETAMIDE DERIVATIVES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1796657A2

  公开（公告）日：2007-06-20
• N-2 Adamantanyl-2-Phenoxy-Acetamide Derivatives as 11-Beta Hydroxysteroid Dehydrogenase Inhibitors
  申请人：Jaroskova Libuse

  公开号：US20080064693A1

  公开（公告）日：2008-03-13

  The N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 1, 2, 3, or 4; Z represents O, S, NR 6 , SO or SO 2 ; R 1 represent hydrogen, cyano, hydroxy, or C 1-4 alkyl optionally substituted with halo, R 2 represents hydrogen, C 1-4 alkyl, or C 1-4 alkyloxy-; R 3 represents hydrogen, C 1-4 alkyl, C 1-4 alkyloxy- or R 3 combined with R 2 form together a divalent radical selected from the group consisting of —O—CH 2 — (a), —NR 7 —CH 2 — (b), —(CR 8 R 9 ) m — (c) and —CR 10 ═ (d) wherein m represents 1 or 2 and R 7 , R 8 , R 9 and R 10 are each independently selected from hydrogen or C 1-4 alkyl; R 4 represents hydrogen, halo, hydroxy, cyano, amino, NR 11 R 12 , C 1-4 alkyloxy-optionally substituted with one or where possible two or three substituents selected from hydroxy and halo or R 4 represents C 1-4 alkyl optionally substituted with one or where possible two or three substituents selected from hydroxy and halo; R 5 represents hydrogen, halo, cyano, amino, phenyl, hydroxy, C 1-4 alkyloxycarbonyl, hydroxycarbonyl, NR 13 R 14 or C 1-4 alkyl substituted with one or more substituents selected from hydroxycarbonyl, phenyl, C 1-4 alkyloxy or NR 15 R 16 ; R 6 represents hydrogen; R 11 and R 12 each independently represent hydrogen, C 1-4 alkyl or C 1-4 alkylcarbonyl-; R 13 and R 14 each independently represent hydrogen, C 1-4 alkyl or C 1-4 alkylcarbonyl-; R 15 and R 16 each independently represent hydrogen, C 1-4 alkyl or C 1-4 alkylcarbonyl-; R 17 and R 18 each independently represent hydrogen, C 1-4 alkyl or C 1-4 alkylcarbonyl-.
• US8344181B2
  申请人：——

  公开号：US8344181B2

  公开（公告）日：2013-01-01
• [EN] N-2 ADAMANTANYL-2-PHENOXY-ACETAMIDE DERIVATIVES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS<br/>[FR] DERIVES D'ACETAMIDES N-2 ADAMANTANYL-2-PHENOXY UTILISES EN TANT QU'INHIBITEURS DE LA DESHYDROGENASE 11-BETA HYDROXYSTEROIDE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2006024627A2

  公开（公告）日：2006-03-09

  The N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 1, 2, 3, or 4; Z represents O, S, NR6, SO or SO2; R1 represent hydrogen, cyano, hydroxy, or C1-4alkyl optionally substituted with halo, R2 represents hydrogen, C1-4alkyl, or C1-4alkyloxy-; R3 represents hydrogen, C1-4alkyl, C1-4alkyloxy- or R3 combined with R2 form together a divalent radical selected from the group consisting of -O-CH2- (a), -NR7-CH2- (b), -(CR8R9)m- (c) and -CR10= (d) wherein m represents 1 or 2 and R7, R8, R9 and R10 are each independently selected from hydrogen or C1-4alkyl; R4 represents hydrogen, halo, hydroxy, cyano, amino, NR11R12, C1-4alkyloxy- optionally substituted with one or where possible two or three substituents selected from hydroxy and halo or R4 represents C1-4alkyl optionally substituted with one or where possible two or three substituents selected from hydroxy and halo; R5 represents hydrogen, halo, cyano, amino, phenyl, hydroxy, C1-4alkyloxycarbonyl, hydroxycarbonyl, NR13R14 or C1-4alkyl substituted with one or more substituents selected from hydroxycarbonyl, phenyl, C1-4alkyloxy or NR15R16; R6 represents hydrogen; R11 and R12 each independently represent hydrogen, C1-4 alkyl or C1-4 alkylcarbonyl-; R13 and R14 each independently represent hydrogen, C1-4 alkyl or C1-4 alkylcarbonyl-; R15 and R16 each independently represent hydrogen, C1-4 alkyl or C1-4 alkylcarbonyl-; R17 and R18 each independently represent hydrogen, C1-4 alkyl or C1-4 alkylcarbonyl-.