3-Cyclohexyl-N-hydroxy-acrylamide | 651738-75-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-Cyclohexyl-N-hydroxy-acrylamide
• 英文别名: 3-Cyclohexyl-N-hydroxyprop-2-enamide；3-cyclohexyl-N-hydroxyprop-2-enamide
• CAS: 651738-75-9
• 化学式: C₉H₁₅NO₂
• 分子量: 169.224
• InChiKey: LXIOHJHWOFKOBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-cyclohexylacrylic acid 在 盐酸羟胺 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 18.5h， 生成 3-Cyclohexyl-N-hydroxy-acrylamide
  参考文献：
  名称：

  [EN] NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS
  [FR] NOUVEAUX COMPOSES UTILISES COMME INHIBITEURS DE L'HISTONE-DEACETYLASE

  摘要：

  本发明涉及通式（I）的化合物或其药用可接受盐或生理功能衍生物，其中：n是一个非芳香环系统，含有两至七个碳原子，环系统可以包含一个或两个双键；X是C、CH或CH2；Y从C、CH、CH2、S、NR、CH2-CH2、H2C--CH、HC--CH2、C--CH2、H2C--C或C--C中选择；一个或多个氢原子可以选择性地被一个或多个取代基R取代；每个虚线表示单键、双键或三键，但不包括三键与三键的组合和双键与三键的组合；R独立地是H、-CN、烷基、环烷基、氨基烷基、烷基氨基、烷氧基、-OH、-SH、烷基硫基、羟基烷基、羟基烷基氨基、卤素、卤代烷基、卤代烷氧基；R是H、烷基或环烷基；Z是CH、C或P；p为0或1。

  公开号：

  WO2004009536A1

文献信息

• [EN] NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSES UTILISES COMME INHIBITEURS DE L'HISTONE-DEACETYLASE
  申请人：4SC AG

  公开号：WO2004009536A1

  公开（公告）日：2004-01-29

  The present invention is directed to compounds of the general formula (I) or pharmaceutical acceptable salts or physiologically functional derivatives thereof wherein: n is a non-aromatic ring system containing two to seven carbon atoms, wherein the ring system can contain one ore two double bonds; X is C, CH or CH2; Y is selected from C, CH, CH2, S, NR, CH2-CH2, H2C- -CH, HC- -CH2, C- -CH2, H2C- -C,or C - -C; one or more of the hydrogen atoms can opionally be substituted by one or more substituents R ; each of the dotted lines means a single, a double or triple bond with the exclusion of a combination of a triple with triple bond and a double with a triple bond; R is independently H, -CN, alkyl, cycloalkyl, aminoalkyl, alkylamino, alkoxy, -OH, -SH, alkylthio, hydroxyalkyl, hydroxyalkylamino, halogene, haloalkyl, haloalkyloxy; R is H, an alkyl or cycloalkyl group; Z is CH, C, or P; p is 0 or 1.

  本发明涉及通式（I）的化合物或其药用可接受盐或生理功能衍生物，其中：n是一个非芳香环系统，含有两至七个碳原子，环系统可以包含一个或两个双键；X是C、CH或CH2；Y从C、CH、CH2、S、NR、CH2-CH2、H2C--CH、HC--CH2、C--CH2、H2C--C或C--C中选择；一个或多个氢原子可以选择性地被一个或多个取代基R取代；每个虚线表示单键、双键或三键，但不包括三键与三键的组合和双键与三键的组合；R独立地是H、-CN、烷基、环烷基、氨基烷基、烷基氨基、烷氧基、-OH、-SH、烷基硫基、羟基烷基、羟基烷基氨基、卤素、卤代烷基、卤代烷氧基；R是H、烷基或环烷基；Z是CH、C或P；p为0或1。
• NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS
  申请人：Maurer Alexander B.

  公开号：US20090088478A1

  公开（公告）日：2009-04-02

  The present invention relates to compounds as inhibitors of enzymes having histone deacetylase activity, to the processes for the preparation of those compounds, and to their use for the treatment of diseases which are associated with hypoacetylation of histones and/or other molecules, or in which induction of hyperacetylation has a beneficial effect for example by inhibition of proliferation and/or induction of differentiation and/or induction of apoptosis in transformed cells, such as cancer. Furthermore, the compounds are useful for the treatment of other proliferative diseases, for therapy or prophylaxis of conditions associated with abnormal gene expression.

  本发明涉及化合物，作为组织脱乙酰化酶活性的抑制剂，以及制备这些化合物的方法，以及它们用于治疗与组织缺乏乙酰化和/或其他分子相关的疾病，或者诱导过度乙酰化具有益处的疾病，例如通过抑制增殖和/或诱导转化细胞中的分化和/或诱导凋亡，如癌症。此外，这些化合物对于治疗其他增生性疾病，治疗或预防与异常基因表达相关的疾病也有用。
• Compounds as histone deacetylase inhibitors
  申请人：4SC Discovery GmbH

  公开号：US08227516B2

  公开（公告）日：2012-07-24

  The present invention relates to compounds as inhibitors of enzymes having histone deacetylase activity, to the processes for the preparation of those compounds, and to their use for the treatment of diseases which are associated with hypoacetylation of histones and/or other molecules, or in which induction of hyperacetylation has a beneficial effect for example by inhibition of proliferation and/or induction of differentiation and/or induction of apoptosis in transformed cells, such as cancer. Furthermore, the compounds are useful for the treatment of other proliferative diseases, for therapy or prophylaxis of conditions associated with abnormal gene expression.

  本发明涉及作为酶抑制剂的化合物，这些酶具有组蛋白去乙酰化酶活性，以及制备这些化合物的过程，以及它们用于治疗与组蛋白和/或其他分子低乙酰化相关的疾病，或在其中诱导高乙酰化具有益处的情况下的使用，例如通过抑制增殖和/或诱导转化细胞中的分化和/或诱导凋亡，如癌症。此外，这些化合物对于治疗其他增殖性疾病，用于治疗或预防与异常基因表达相关的疾病也是有用的。
• Novel compounds as histone deacetylase inhibitors
  申请人：Maurer B. Alexander

  公开号：US20050176686A1

  公开（公告）日：2005-08-11

  The present invention is directed to compounds of the general formula (I) or pharmaceutical acceptable salts or physiologically functional derivatives thereof wherein: n is a non-aromatic ring system containing two to seven carbon atoms, wherein the ring system can contain one ore two double bonds; X is C, CH or CH 2 ; Y is selected from C, CH, CH 2 , S, NR, CH 2 -CH 2 , H 2 C—CH, HC—CH 2 , C—CH 2 , H 2 C—C, or C—C; one or more of the hydrogen atoms can optionally be substituted by one or more substituents R′; each of the dotted lines means a single, a double or triple bond with the exclusion of a combination of a triple with triple bond and a double with a triple bond; R′ is independently H, —CN, alkyl, cycloalkyl, aminoalkyl, alkylamino, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, hydroxyalkylamino, halogene, haloalkyl, haloalkyloxy; R is H, an alkyl or cycloalkyl group; Z is CH, C, or P; p is 0 or 1.

  本发明涉及一般式(I)的化合物或其药用可接受的盐或生理功能衍生物，其中：n是一个含有两至七个碳原子的非芳香环系统，其中该环系统可以包含一个或两个双键；X是C、CH或CH2；Y从C、CH、CH2、S、NR、CH2-CH2、H2C—CH、HC—CH2、C—CH2、H2C—C或C—C中选择；其中一个或多个氢原子可以选择性地被一个或多个取代基R′取代；每个虚线表示单键、双键或三键，不包括三键与三键的组合和双键与三键的组合；R′独立地是H、—CN、烷基、环烷基、氨基烷基、烷基氨基、烷氧基、—OH、—SH、烷基硫基、羟基烷基、羟基氨基烷基、卤素、卤代烷基、卤代烷氧基；R是H、烷基或环烷基；Z是CH、C或P；p是0或1。