(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8-methyl-N-[(3S)-2-oxo-1-[(2,3,4,5,6-pentafluorophenyl)methyl]azepan-3-yl]dec-6-enamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8-methyl-N-[(3S)-2-oxo-1-[(2,3,4,5,6-pentafluorophenyl)methyl]azepan-3-yl]dec-6-enamide
• 化学式: C₂₅H₃₃F₅N₂O₆
• 分子量: 552.5
• InChiKey: RXRWZANWNASIKF-BTSORPKRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  38
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  119
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• BENGAMIDES WITH A SUBSTITUTED CAPROLACTAME CYCLE, METHOD FOR THE PREPARATION THEREOF, COMPOSITIONS CONTAINING THEM AND USE THEREOF
  申请人：Zhang Jidong

  公开号：US20070249584A1

  公开（公告）日：2007-10-25

  The invention relates to the preparation of substituted caprolactams, a method for the preparation thereof, compositions containing them and the use thereof as a medicament, particularly as anticancer agents.

  这项发明涉及取代环己内酰胺的制备，制备方法，包含它们的组合物以及将其用作药物，特别是抗癌剂的用途。
• BENGAMIDES POSSEDANT UN CYCLE CAPROLACTAME SUBSTITUE, PROCEDE DE PREPARATION, COMPOSITIONS LES CONTENANT ET UTILISATION
  申请人：Aventis Pharma S.A.

  公开号：EP1819680B1

  公开（公告）日：2012-02-15
• BENGAMIDES WITH A SUBSTITUTED CAPROLACTAM CYCLE, METHOD FOR THE PREPARATION THEREOF, COMPOSITIONS CONTAINING THEM AND USE THEREOF
  申请人：ZHANG Jidong

  公开号：US20080318928A1

  公开（公告）日：2008-12-25

  The invention relates to the preparation of substituted caprolactams, a method for the preparation thereof, compositions containing them and the use thereof as a medicament, particularly as anticancer agents.
• US7585855B2
  申请人：——

  公开号：US7585855B2

  公开（公告）日：2009-09-08