2-fluoro-N'-hydroxy-4-[3-[1-[1-[4-(N'-hydroxycarbamimidoyl)phenoxy]propyl]piperidin-4-yl]propoxy]benzenecarboximidamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-fluoro-N'-hydroxy-4-[3-[1-[1-[4-(N'-hydroxycarbamimidoyl)phenoxy]propyl]piperidin-4-yl]propoxy]benzenecarboximidamide
• 化学式: C₂₅H₃₄FN₅O₄
• 分子量: 487.6
• InChiKey: BBANZEYKHXMEFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  139
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• PHARMACEUTICAL COMPOSITION AND METHOD USING ANTIFUNGAL AGENT IN COMBINATION
  申请人：TOYAMA CHEMICAL CO., LTD.

  公开号：EP1867332A1

  公开（公告）日：2007-12-19

  A pharmaceutical composition containing one or more antifungal agents selected from an arylamidine derivative represented by the general formula: (wherein R1 represents an amidino group that may be substituted with a hydroxyl group that may be protected with an acyl group, an amidino group that may be substituted with an alkoxy group that may be substituted, or an amidino group that may be substituted with an aralkyloxy group that may be substituted; R2 and R3 identically or differently represent a hydrogen atom or a halogen atom) or a salt thereof, an azole antifungal agent, a polyene antifungal agent, a candin antifungal agent and a fluoropyrimidine antifungal agent has a strong antifungal activity and is useful for the treatment of fungal infection. A method for using them in combination is useful as an excellent therapeutic method for fungal infection. A pharmaceutical composition containing the arylamidine derivative represented by the above general formula or a salt thereof and an immunosuppressant has a strong antifungal activity and is useful for the treatment of fungal infection and a skin disease such as atopic dermatitis. A method for using them in combination is useful as an excellent therapeutic method for fungal infection and a skin disease such as atopic dermatitis.

  一种药物组合物，含有一种或多种抗真菌剂，这些抗真菌剂选自由通式表示的芳基脒衍生物： (其中 R1 代表可被可被酰基保护的羟基取代的脒基，可被可被取代的烷氧基取代的脒基，或可被可被取代的烷氧基取代的脒基；R2和R3相同或不同地代表氢原子或卤原子）或其盐，唑类抗真菌剂、多烯类抗真菌剂、坎丁类抗真菌剂和氟嘧啶类抗真菌剂具有很强的抗真菌活性，可用于治疗真菌感染。将它们联合使用的方法是治疗真菌感染的有效方法。含有上述通式代表的芳基脒衍生物或其盐和免疫抑制剂的药物组合物具有很强的抗真菌活性，可用于治疗真菌感染和皮肤病，如特应性皮炎。将它们结合使用的方法是治疗真菌感染和特应性皮炎等皮肤病的有效方法。