6-amino-2-(butylamino)-9-[2-(tetrahydro-3-furanyl)ethyl]-7,9-dihydro-8H-purin-8-one | 1050491-03-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 6-amino-2-(butylamino)-9-[2-(tetrahydro-3-furanyl)ethyl]-7,9-dihydro-8H-purin-8-one
• 英文别名: 6-amino-2-(butylamino)-9-[2-(oxolan-3-yl)ethyl]-7H-purin-8-one
• CAS: 1050491-03-6
• 化学式: C₁₅H₂₄N₆O₂
• 分子量: 320.395
• InChiKey: ZIOHFNFXSGRLFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-(2'-hydroxyethyl)tetrahydrofuran 在 盐酸 、 甲醇 、 potassium carbonate 、 三乙胺 、 lithium bromide 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 24.5h， 生成 6-amino-2-(butylamino)-9-[2-(tetrahydro-3-furanyl)ethyl]-7,9-dihydro-8H-purin-8-one
  参考文献：
  名称：

  WO2008/101867

  摘要：

  公开号：

文献信息

• PURINE DERIVATIVES AS IMMUNOMODULATORS
  申请人：Lazarides Linos

  公开号：US20100120799A1

  公开（公告）日：2010-05-13

  Compounds of formula (I): wherein R 1 is C 1-8 alkylamino, C 1-8 alkoxy, C 3-7 cycloalkylC 1-6 alkylamino, C 3-7 cycloalkylC 1-6 alkoxy, C 1-3 alkoxyC 2-3 alkoxy, or Het b -C 1-3 alkoxy; Het b is a 5- or 6-membered saturated aliphatic heterocycle containing one oxygen atom; R 2 is —(CH 2 ) n -Het; n is an integer having a value of 1 to 4; Het is a 5- or 6-membered saturated aliphatic heterocycle containing one oxygen heteroatom, which heterocycle may be substituted by one or two C 1-4 alkyl groups, and salts and solvates thereof, are inducers of human interferon and may be useful in the treatment of various disorders in particular infectious diseases, cancer, and allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, and as vaccine adjuvants.

  化合物的式子(I)：其中R1是C1-8烷基氨基，C1-8烷氧基，C3-7环烷基C1-6烷基氨基，C3-7环烷基C1-6烷氧基，C1-3烷氧基C2-3烷氧基或Hetb-C1-3烷氧基；Hetb是含有一个氧原子的5-或6-成员饱和脂肪族杂环；R2是—(CH2)n-Het；n是一个值为1到4的整数；Het是含有一个氧杂原子的5-或6-成员饱和脂肪族杂环，该杂环可能被一个或两个C1-4烷基基团取代，以及其盐和溶剂化物，是人类干扰素的诱导剂，可用于治疗各种疾病，特别是感染性疾病、癌症、过敏性疾病和其他炎症状况，例如过敏性鼻炎和哮喘，并作为疫苗佐剂。
• COMPOUNDS
  申请人：Lazarides Linos

  公开号：US20110269781A1

  公开（公告）日：2011-11-03

  The present invention includes novel compounds useful in the treatment of various disorders in particular infectious diseases, cancer, and allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, and as vaccine adjuvants.

  本发明涵盖了新型化合物，可用于治疗各种疾病，特别是感染性疾病、癌症、过敏性疾病和其他炎症病症，例如过敏性鼻炎和哮喘，并可用作疫苗佐剂。
• Compounds
  申请人：GlaxoSmithKline LLC

  公开号：US07977344B2

  公开（公告）日：2011-07-12

  The present invention includes novel compounds useful in the treatment of various disorders in particular infectious diseases, cancer, and allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, and as vaccine adjuvants.

  本发明包括新型化合物，可用于治疗各种疾病，特别是感染性疾病、癌症、过敏性疾病和其他炎症状况，例如过敏性鼻炎和哮喘，并作为疫苗佐剂。
• COATING MATERIAL, LAYERED PRODUCT, AND PROCESS FOR PRODUCING CYLINDRICAL LAYERED PRODUCT
  申请人：I.S.T. Corporation

  公开号：EP2143770A1

  公开（公告）日：2010-01-13

  The object of the present invention is to provide a coating material for coating from which a fixing belt that meets demand characteristics such as heat resistance to fixing temperatures and releasibility toward toner can be manufactured at low cost, and to provide the coating material for coating that does not produce "sag", "slack", or uneven thickness in a fluororesin coating film. The coating material for coating according to the present invention comprises fluororesin particles, a liquid dispersion of volatile resin particles, a thixotropy-imparting agent and an organic solvent. The liquid dispersion of volatile resin particles contains volatile resin particles and a nonvolatile portion. Furthermore, the volatile resin particles are resin particles that undergo volatilization or thermal decomposition at a temperature lower than the thermal decomposition temperature of fluororesin. Moreover, the nonvolatile portion is contained at ≥5 parts by weight based on 100 parts by weight of fluororesin particles.

  本发明的目的是提供一种涂布用涂层材料，用这种材料可以低成本制造出符合要求特性的定影带，如耐热定影温度和对调色剂的释放性，并提供不会在氟树脂涂膜中产生 "下垂"、"松弛 "或厚度不均匀的涂布用涂层材料。根据本发明，用于涂布的涂层材料包括氟树脂颗粒、挥发性树脂颗粒的液态分散体、触变引发剂和有机溶剂。挥发性树脂颗粒液态分散体包含挥发性树脂颗粒和非挥发性部分。此外，挥发性树脂颗粒是在低于氟树脂热分解温度下发生挥发或热分解的树脂颗粒。此外，以 100 份氟树脂颗粒的重量为基准，不挥发部分的重量≥5 份。
• METHOD FOR THE MANUFACTURE OF A CYLINDRICAL LAMINATED BODY, AND LAMINATED BODY
  申请人：Sandaiji Takanobu

  公开号：US20100129580A1

  公开（公告）日：2010-05-27

  A manufacturing method for the cylindrical laminated body includes superimposing application step, a solvent removal step and an imidization step. In the superimposing application step, a coating material containing fluororesin particles and a polyimide precursor solution are applied in a superimposing manner on a core body. In the solvent removal step, the solvent is removed from the coating material and the polyimide precursor solution. In the imidization step, the polyimide precursor is imidized along with the formation of the coating material into a covering film.