N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)-N'-benzyl-3,4,5,6-tetrahydrophthalamide | 153390-04-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)-N'-benzyl-3,4,5,6-tetrahydrophthalamide
• 英文别名: 1-N-benzyl-2-N-(4-chloro-5-cyclopentyloxy-2-fluorophenyl)cyclohexene-1,2-dicarboxamide
• CAS: 153390-04-6
• 化学式: C₂₆H₂₈ClFN₂O₃
• 分子量: 470.971
• InChiKey: GWIJRGYDHJWRTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)-3,4,5,6-tetrahydrophthalimide 、 苄胺 在 正己烷 作用下， 以 苯 为溶剂， 反应 16.0h， 以to obtain N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)-N'-benzyl-3,4,5,6-tetrahydrophthalamide as white crystals (0.584 g, 45.1% yield)的产率得到N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)-N'-benzyl-3,4,5,6-tetrahydrophthalamide
  参考文献：
  名称：

  Tetrahydrophthalamide derivative, intermediate for producing the same,

  摘要：

  本发明涉及3,4,5,6-四氢酞酰亚胺衍生物和3,4,5,6-四氢异酞酰亚胺衍生物，作为优良的除草剂有效活性成分，并提供制备它们的方法，提供具有更高效的除草活性的化合物和高效工业制备它们的方法。更具体地说，通过将卤代5-环烷氧基苯胺衍生物与3,4,5,6-四氢酞酸酐反应得到的四氢酞酰亚胺衍生物，或者本发明的四氢异酞酰亚胺衍生物与各种类型的胺反应，制备出由通式（I）表示的四氢酞酰亚胺衍生物：##STR1## 这些四氢酞酰亚胺衍生物和四氢异酞酰亚胺衍生物在稻田和田野的土壤处理和茎叶处理中表现出优越的除草活性。四氢异酞酰亚胺衍生物还可用作制备四氢酞酰亚胺衍生物等的中间体。

  公开号：

  US05554581A1

文献信息

• TETRAHYDROPHTHALAMIDE DERIVATIVE, INTERMEDIATE FOR PRODUCING THE SAME, PRODUCTION OF BOTH, AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP0635485A1

  公开（公告）日：1995-01-25

  A 3,4,5,6-tetrahydrophthalamide derivative and a 3,4,5,6-tetrahydroisophthalimide derivative, both having an excellent efficay as the active ingredient of a herbicide, and an industrial process for efficiently producing these higher-performance, herbicidally active compounds. A tetrahydrophthalamide derivative represented by general formula (I) is produced by the reaction of a tetrahydrophthalimide derivative, prepared by the reaction of a halogenated 5-cycloalkyloxyaniline derivative with 3,4,5,6-tetrahydrophthalic anhydride, or of the tetrahydroisophthalimide derivative of the invention with various amines. These tetrahydrophthalamide and tetrahydroisophthalimide derivatives have an excellent herbicidal effect in the treatment of lowland and upland soils and foliage treatment. The tetrahydroisophthalimide derivative is useful also as an intermediate for producing the tetrahydrophthalamide derivative and the like.

  一种3,4,5,6-四氢邻苯二甲酰胺衍生物和一种3,4,5,6-四氢异邻苯二甲酰亚胺衍生物，这两种衍生物作为除草剂的活性成分具有极佳的功效，以及一种高效生产这些性能更佳、除草活性更强的化合物的工业工艺。通过卤化 5-环烷氧基苯胺衍生物与 3,4,5,6-四氢邻苯二甲酸酐反应制备的四氢邻苯二甲酰亚胺衍生物，或本发明的四氢异邻苯二甲酰亚胺衍生物与各种胺反应制备通式 (I) 所代表的四氢邻苯二甲酰亚胺衍生物。这些四氢邻苯二甲酰胺和四氢异邻苯二甲酰亚胺衍生物在处理低地和高地土壤和叶片方面具有极佳的除草效果。四氢异邻苯二甲酰亚胺衍生物还可用作生产四氢邻苯二甲酰胺衍生物等的中间体。
• US5506190A
  申请人：——

  公开号：US5506190A

  公开（公告）日：1996-04-09
• US5554581A
  申请人：——

  公开号：US5554581A

  公开（公告）日：1996-09-10
• Tetrahydrophthalamide derivative, intermediate for producing the same,
  申请人：Sagami Chemical Research Center

  公开号：US05506190A1

  公开（公告）日：1996-04-09

  The present invention relates to 3,4,5,6-tetrahydrophthalamide derivatives and 3,4,5,6-tetrahydroisophthalimide derivatives having excellent effects as effective active ingredients of herbicides, and processes for preparing the same, and provides the compounds having a more efficient herbicidal activity, and efficient and industrial processes for the preparation thereof. More specifically, the tetrahydrophthalimide derivative obtained by reacting a halogen-substituted 5-cycloalkyloxyaniline derivative with a 3,4,5,6-tetrahydrophthalic anhydride, or the tetrahydroisophthalimide derivative of the present invention is reacted with various types of amines to prepare a tetrahydrophthalamide derivative represented by the general formula (I): ##STR1## These tetrahydrophthalamide derivatives and the tetrahydroisophthalimide derivatives exhibit excellent herbicidal activities in the soil treatment in the paddy field and field and the stem-foliar treatment. The tetrahydroisophthalimide derivatives are also useful as intermediates for the preparation of the tetrahydrophthalamide derivatives, etc.

  本发明涉及具有卓越除草剂有效活性成分的3,4,5,6-四氢邻苯二酰胺衍生物和3,4,5,6-四氢异苯二酰胺衍生物，以及其制备方法，并提供具有更高效的除草活性的化合物，以及其高效和工业化的制备方法。更具体地，通过将卤素取代的5-环烷氧基苯胺衍生物与3,4,5,6-四氢邻苯二酐反应获得的四氢邻苯二酰胺衍生物，或者将本发明的四氢异苯二酰胺衍生物与各种类型的胺反应以制备由通式（I）表示的四氢邻苯二酰胺衍生物：这些四氢邻苯二酰胺衍生物和四氢异苯二酰胺衍生物在稻田和田间土壤处理以及茎叶处理中表现出卓越的除草活性。四氢异苯二酰胺衍生物还可用作制备四氢邻苯二酰胺衍生物等的中间体。