1-Hydroxysulfanyl-4-(trifluoromethoxy)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-Hydroxysulfanyl-4-(trifluoromethoxy)benzene
• 英文别名: 1-hydroxysulfanyl-4-(trifluoromethoxy)benzene
• 化学式: C₇H₅F₃O₂S
• 分子量: 210.18
• InChiKey: PROPQGBVESVQLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  54.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] BILE ACID DERIVATIVES AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF<br/>[FR] DÉRIVÉS D'ACIDE BILIAIRE UTILISÉS COMME AGONISTES DE FXR/TGR5 ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ENANTA PHARM INC

  公开号：WO2016086134A1

  公开（公告）日：2016-06-02

  The present invention provides compounds of amino-substituted bile acid compounds, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions. In another embodiment, the present invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound or combination of compounds of the present invention, or a pharmaceutically acceptable salt form, stereoisomer, solvate, hydrate or combination thereof, in combination with a pharmaceutically acceptable carrier or excipient.