[4-(2,5-Dimethylpyrrol-1-yl)phenyl] 4-methylbenzenesulfonate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: [4-(2,5-Dimethylpyrrol-1-yl)phenyl] 4-methylbenzenesulfonate
• 化学式: C₁₉H₁₉NO₃S
• 分子量: 341.4
• InChiKey: OWDKFDPBHFADQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  56.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• EphA4 INHIBITORS AS NEUROPROTECTIVE AGENTS
  申请人：THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

  公开号：US20160152618A1

  公开（公告）日：2016-06-02

  Provided is the discovery of the role of EphA4 signaling in neurodegenerative disorders involving β-amyloid induced neurotoxicity such as Alzheimer's Disease. New therapeutic methods, therapeutic agents, and kits for treating diseases caused or exacerbated by overactivated EphA4 signaling are provided. Also provided are methods for identifying additional compounds as therapeutic agents useful for treating conditions involving overly active EphA4 signaling.
• US9629830B2
  申请人：——

  公开号：US9629830B2

  公开（公告）日：2017-04-25