O-[1-[di(octadec-9-enoyl)amino]propan-2-yl] hexadecanethioate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: O-[1-[di(octadec-9-enoyl)amino]propan-2-yl] hexadecanethioate
• 化学式: C₅₅H₁₀₃NO₃S
• 分子量: 858.5
• InChiKey: YZRKDBVXTOUDJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  22.7
• 重原子数：
  60
• 可旋转键数：
  48
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  78.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Therapeutic use of acyl glycerols and the nitrogen- and sulphur- containing analogues thereof
  申请人：Darteil Raphael

  公开号：US20060154984A1

  公开（公告）日：2006-07-13

  The invention relates to the use of acyl glycerols and the nitrogen- and sulfur-containing analogues thereof in the therapeutic field, particularly in human health. The inventive compounds have advantageous pharmacological properties and are particularly of use for the prevention or treatment of neurodegenerative diseases.

  这项发明涉及在治疗领域中使用酰基甘油及其氮和硫含量类似物，特别是在人类健康领域。这些创新化合物具有有益的药理特性，特别适用于预防或治疗神经退行性疾病。
• Acylated aminopropanediols and analogues and therapeutic uses thereof
  申请人：Darteil Raphael

  公开号：US20060069156A1

  公开（公告）日：2006-03-30

  The invention relates to novel acylated aminopropanediols and the nitrogen and sulfur analogues thereof, pharmaceutical compositions comprising same, therapeutic uses thereof, in particular for the treatment of cerebral ischemia. The invention also provides a method of preparing said derivatives.

  该发明涉及新型酰化氨基丙二醇及其氮和硫类似物，包括这些化合物的药物组合物，其治疗用途，特别是用于治疗脑缺血。该发明还提供了制备这些衍生物的方法。
• Uses of acylated aminopropanediols and sulphur and nitrogen analogues of same f
  申请人：Najib Jamila

  公开号：US20060035977A1

  公开（公告）日：2006-02-16

  The invention relates to the use of molecules, particularly in the fields of human and veterinary health and cosmetics. The inventive compounds are acylated aminopropanediols and the nitrogen- and sulfur-containing analogues thereof and have advantageous pharmacological and cosmetic properties. In particular, the inventive compounds can be used to prevent and/or treat dyslipidemias, cardiovascular diseases, syndrome X, restenosis, diabetes, obesity, hypertension, some cancers, dermatological diseases, and, in the field of cosmetics, to combat skin ageing and the effects of same, in particular the development of wrinkles and the like.

  这项发明涉及分子的使用，特别是在人类和兽医健康以及化妆品领域。这些创新化合物是酰化氨基丙二醇及其氮和硫含量的类似物，具有有益的药理学和化妆品特性。特别是，这些创新化合物可以用于预防和/或治疗脂质代谢异常、心血管疾病、X综合征、再狭窄、糖尿病、肥胖、高血压、某些癌症、皮肤病，以及在化妆品领域中，用于对抗皮肤衰老及其效应，特别是皱纹等的发展。
• US7253296B2
  申请人：——

  公开号：US7253296B2

  公开（公告）日：2007-08-07