苄基青霉素氯咪唑 | 6011-39-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 苄基青霉素氯咪唑
• 中文别名: 氯咪唑青霉素；克咪西林；咪唑西林
• 英文名称: penicillin G clemizole
• 英文别名: 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ium-1-ylmethyl)benzimidazole;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• CAS: 6011-39-8
• 化学式: C35H38ClN5O4S
• 分子量: 660.2
• InChiKey: GKPMEGXMKPQRTN-CBDIPHIASA-N

物化性质

• 熔点：
  144-145°
• 比旋光度：
  D24 +144.5° (c = 10 in DMF)

计算性质

• 辛醇/水分配系数(LogP)：
  5.19
• 重原子数：
  46
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] COMPOUNDS AND METHODS OF TREATING BACTERIAL INFECTIONS<br/>[FR] COMPOSÉS ET MÉTHODES DE TRAITEMENT D'INFECTIONS BACTÉRIENNES
  申请人：ULTUPHARMA AB

  公开号：WO2017095319A1

  公开（公告）日：2017-06-08

  The invention relates to compounds of Formula (I), wherein the variables are as defined in the claims, which are useful in the treatment and/or prevention of bacterial infections in a subject. The invention further relates to the use of a compound of Formula (I) in the manufacture of a medicament, and medical devices when used in a method of treating or preventing a bacterial infection in a subject, and related aspects.

  该发明涉及式（I）的化合物，其中变量如权利要求中所定义，这些化合物在治疗和/或预防受试者的细菌感染方面是有用的。该发明还涉及使用式（I）的化合物制造药物，以及在治疗或预防受试者的细菌感染方法中使用时的医疗器械，以及相关方面。
• [EN] METHODS AND COMPOSITIONS FOR TREATING EPILEPSY<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DE L'ÉPILEPSIE
  申请人：UNIV CALIFORNIA

  公开号：WO2020243349A1

  公开（公告）日：2020-12-03

  Provided, inter alia, are methods and compositions for treating epilepsy. In one aspect, provided herein is a method of selecting a compound for treating epilepsy, said method includes, contacting a test compound with 5-hydroxytryptamine-2B receptor (5-HT2B), and measuring the 5-HT2B agonistic activity of the test compound. In another aspect, provided herein is a method of treating an epilepsy in a subject in need thereof. The method includes administering to said subject an effective amount of a 5-HT2B specific receptor agonist.

  提供了治疗癫痫的方法和组合物。在一个方面，本文提供了一种选择治疗癫痫化合物的方法，该方法包括将测试化合物与5-羟色胺-2B受体（5-HT2B）接触，并测量测试化合物的5-HT2B激动活性。在另一个方面，本文提供了一种治疗患有癫痫的受试者的方法。该方法包括向该受试者施用有效量的5-HT2B特异性受体激动剂。
• Large-scale manufacturing process for the production of pharmaceutical compositions
  申请人：Banach Maria

  公开号：US20060073173A1

  公开（公告）日：2006-04-06

  Methods for manufacturing pharmaceutical compositions with a predetermined surface tension or other properties are provided. Also provided are pharmaceutical compositions with a predetermined surface tension or other properties, articles of manufacture containing the pharmaceutical compositions and systems for preparation of the compositions.

  提供了制造具有预定表面张力或其他性质的制药组合物的方法。还提供了具有预定表面张力或其他性质的制药组合物，包含制药组合物的制品以及制备组合物的系统。
• COMPOUNDS AND METHODS OF TREATING INFECTIONS
  申请人：GARG Sanjay

  公开号：US20160075665A1

  公开（公告）日：2016-03-17

  The invention provides compounds of Formula (I), and methods of treating or preventing a bacterial infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a bacterial infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a bacterial infection in a subject and to a medical device comprising the composition of the invention.

  本发明提供了化合物(I)的方法，以及使用化合物(I)治疗或预防受体内细菌感染的方法。本发明还提供了使用化合物(I)制造治疗受体内细菌感染的药物的方法。本发明还提供了在治疗或预防受体内细菌感染的方法中使用的医疗设备，以及包含本发明化合物的医疗设备。
• An otorhinological drug delivery device
  申请人：Schering Oy

  公开号：EP1438942A1

  公开（公告）日：2004-07-21

  The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof.

  本发明涉及一种包含至少一种药用活性剂的耳鼻喉给药装置。根据本发明，该装置包括一个包含所述至少一种药物活性剂的芯体，其中所述芯体由弹性体组合物制成，该弹性体组合物选自聚（二甲基硅氧烷）、硅氧烷基弹性体（包含连接到硅氧烷单元S原子上的3,3,3-三氟丙基）、硅氧烷基弹性体（包含聚（环氧烷）基团）及其混合物组成的组。