6-[3-[(6-Aminopyridin-2-yl)methoxy]propoxymethyl]pyridin-2-amine | 885263-62-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-[3-[(6-Aminopyridin-2-yl)methoxy]propoxymethyl]pyridin-2-amine
• 英文别名: 6-[3-[(6-aminopyridin-2-yl)methoxy]propoxymethyl]pyridin-2-amine
• CAS: 885263-62-7
• 化学式: C₁₅H₂₀N₄O₂
• 分子量: 288.349
• InChiKey: IQQQWFRMEQDIRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  96.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6-[3-[(6-Aminopyridin-2-yl)methoxy]propoxymethyl]pyridin-2-amine 、 4-(N-(4-carbonochloridoylphenyl)anilino)benzoyl chloride 以 四氢呋喃 为溶剂， 反应 24.0h， 以12%的产率得到2-Phenyl-15,19-dioxa-2,8,26,33,34-pentazapentacyclo[26.2.2.23,6.19,13.121,25]hexatriaconta-1(30),3(36),4,6(35),9,11,13(34),21(33),22,24,28,31-dodecaene-7,27-dione
  参考文献：
  名称：

  Triphenylamine-based novel PET sensors in selective recognition of dicarboxylic acids

  摘要：

  The triphenylamine-based chemosensors 1 and 2 have been designed and synthesized, for the first time, for the selective recognition of dicarboxylic acids. Carboxylic acid binding takes place through charge neutral pyridyl amide receptor sites with concomitant quenching Of fluorescence of the triphenylamine moiety. The bindings were examined using H-1 NMR, fluorescence and UV-vis spectroscopic methods. The receptor 1 was found to be selective for glutaric and adipic acids and the macrocycle 2 was specific for 2,2-dimethylmalonic acid. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.02.008
• 作为产物：
  描述：

  2-特戊酰氨基-6-甲基吡啶 在 N-溴代丁二酰亚胺(NBS) 、 sodium hydride 作用下， 以 四氢呋喃 、 四氯化碳 为溶剂， 反应 20.0h， 生成 6-[3-[(6-Aminopyridin-2-yl)methoxy]propoxymethyl]pyridin-2-amine
  参考文献：
  名称：

  Triphenylamine-based novel PET sensors in selective recognition of dicarboxylic acids

  摘要：

  The triphenylamine-based chemosensors 1 and 2 have been designed and synthesized, for the first time, for the selective recognition of dicarboxylic acids. Carboxylic acid binding takes place through charge neutral pyridyl amide receptor sites with concomitant quenching Of fluorescence of the triphenylamine moiety. The bindings were examined using H-1 NMR, fluorescence and UV-vis spectroscopic methods. The receptor 1 was found to be selective for glutaric and adipic acids and the macrocycle 2 was specific for 2,2-dimethylmalonic acid. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.02.008

文献信息

• Triphenylamine-based novel PET sensors in selective recognition of dicarboxylic acids
  作者：Kumaresh Ghosh、Goutam Masanta

  DOI：10.1016/j.tetlet.2006.02.008

  日期：2006.4

  The triphenylamine-based chemosensors 1 and 2 have been designed and synthesized, for the first time, for the selective recognition of dicarboxylic acids. Carboxylic acid binding takes place through charge neutral pyridyl amide receptor sites with concomitant quenching Of fluorescence of the triphenylamine moiety. The bindings were examined using H-1 NMR, fluorescence and UV-vis spectroscopic methods. The receptor 1 was found to be selective for glutaric and adipic acids and the macrocycle 2 was specific for 2,2-dimethylmalonic acid. (c) 2006 Elsevier Ltd. All rights reserved.