N-phenylmethanesulfonyl-DL-norvaline | 107476-25-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-phenylmethanesulfonyl-DL-norvaline
• 英文别名: N-Phenylmethansulfonyl-DL-norvalin；2-(Benzylsulfonylamino)pentanoic acid
• CAS: 107476-25-5
• 化学式: C₁₂H₁₇NO₄S
• mdl: MFCD02641029
• 分子量: 271.337
• InChiKey: RFWTYMRQBJBZIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] PYRAZOLE COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISORDERS<br/>[FR] COMPOSES PYRAZOLE POUR LE TRAITEMENT DE MALADIES NEURODEGENERATIVES
  申请人：PFIZER PROD INC

  公开号：WO2004033434A1

  公开（公告）日：2004-04-22

  The invention provides compounds of Formula (I): wherein R1,R2,R3, R4,R6,R7, R8 and A are as defined. Compounds of formula (I) have activity inhibiting production of Aβ-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula (I).

  该发明提供了Formula (I)的化合物：其中R1、R2、R3、R4、R6、R7、R8和A的定义如上所述。 Formula (I)的化合物具有抑制Aβ-肽产生的活性。 该发明还提供了包含Formula (I)化合物的治疗药物组合物和方法，用于治疗哺乳动物的疾病，例如阿尔茨海默病。
• Pyrazole compounds for treatment of neurodegenerative disorders
  申请人：——

  公开号：US20040142997A1

  公开（公告）日：2004-07-22

  The invention provides compounds of Formula I: 1 wherein R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 8, and A are as defined. Compounds of formula I have activity inhibiting production of A&bgr;-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula I.

  该发明提供了公式I的化合物：1其中R1、R2、R3、R4、R6、R7、R8和A的定义如上所述。公式I的化合物具有抑制Aβ-肽生成的活性。该发明还提供了含有公式I化合物的药物组合物和治疗哺乳动物疾病的方法，例如阿尔茨海默病。
• PYRAZOLE COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISORDERS
  申请人：Chen L. Yuhpyng

  公开号：US20070270474A1

  公开（公告）日：2007-11-22

  The invention provides compounds of Formula I: wherein R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 8 and A are as defined. Compounds of formula I have activity inhibiting production of Aβ-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula I.

  该发明提供了I式化合物：其中R1、R2、R3、R4、R6、R7、R8和A的定义如下。 I式化合物具有抑制Aβ肽的产生活性。该发明还提供了包含I式化合物的药物组合物和治疗哺乳动物疾病的方法，例如阿尔茨海默病。
• Tertiary amine-containing active methylene compounds for improving the dimensional stability of polyurethane foam
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP1099718A2

  公开（公告）日：2001-05-16

  A method for making flexible polyurethane foam in which a polyisocyanate is reacted with a polyol in the presence of a urethane catalyst, a blowing agent, optionally a silicone surfactant cell stabilizer, and a cell opening additive. The cell opening additive comprises an active methylene or methine compound which also contains a tertiary amine. Preferred cell opening additives are 2-cyano-N-[3-(dimethylamino)-propyl]acetamide and (NC)CH2C(O)OCH2CH2N(CH3)CH2CH2OCH2CH2N(CH3)2.

  一种制造软质聚氨酯泡沫塑料的方法，在该方法中，多异氰酸酯与多元醇在聚氨酯催化剂、发泡剂、可选的硅酮表面活性剂气室稳定剂和气室开放添加剂的存在下发生反应。开孔添加剂包括活性亚甲基或甲基化合物，其中还含有叔胺。首选的开孔添加剂是 2-氰基-N-[3-（二甲基氨基）-丙基]乙酰胺和 (NC)CH2C(O)OCH2CH2N(CH3)CH2CH2OCH2CH2N( )2。
• PHOTORESIST STRIPPER COMPOSITION AND PROCESS OF USE
  申请人：MACDERMID, INCORPORATED

  公开号：EP0258417A1

  公开（公告）日：1988-03-09