2-Amino-1-(piperidin-1-yl)propan-1-one

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-1-(piperidin-1-yl)propan-1-one
• 英文别名: 2-amino-1-piperidin-1-ylpropan-1-one
• 化学式: C₈H₁₆N₂O
• mdl: MFCD01474845
• 分子量: 156.23
• InChiKey: WHBVSWNJAJECCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] INHIBITORS OF BRUTON'S TYROSINE KINASE<br/>[FR] INHIBITEURS DE LA TYROSINE KINASE DE BRUTON
  申请人：PHARMACYCLICS LLC

  公开号：WO2016004272A1

  公开（公告）日：2016-01-07

  Disclosed herein are compounds that inhibit Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

  本文披露了抑制布鲁顿酪氨酸激酶（Btk）的化合物。还描述了Btk的不可逆抑制剂。此外，还描述了Btk的可逆抑制剂。还披露了包括这些化合物的药物组合物。披露了使用Btk抑制剂的方法，单独或与其他治疗剂联合治疗自身免疫疾病或症状、异源免疫疾病或症状、癌症（包括淋巴瘤）和炎症性疾病或症状。
• [EN] BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS<br/>[FR] DÉRIVÉS DE SPIRO[2.4]HEPTANE PONTÉS UTILES EN TANT QU'AGONISTES DU RÉCEPTEUR DE ALX ET/OU DU RÉCEPTEUR FPRL2
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2010134014A1

  公开（公告）日：2010-11-25

  The present invention relates to bridged spiro[2.4]heptane derivatives of formula (I), wherein W, Y, Z, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds as ALX receptor and/or FPRL2 agonists for the treatment of inflammatory and obstructive airways diseases.

  本发明涉及桥式螺[2.4]庚烷衍生物的化学式(I)，其中W、Y、Z、R1和R2如描述中所定义，它们的制备及其作为药用活性化合物的ALX受体和/或FPRL2激动剂在治疗炎症性和梗阻性气道疾病中的用途。
• [EN] OPTICAL RESOLUTION OF (1-BENZYL-4-METHYLPIPERIDIN-3-YL) -METHYLAMINE AND THE USE THEREOF FOR THE PREPARATION OF PYRROLO 2,3-PYRIMIDINE DERIVATIVES AS PROTEIN KINASES INHIBITORS<br/>[FR] RESOLUTION OPTIQUE DE (1-BENZYL-4-METHYLPIPERIDINE-3-YLE) METHYLAMINE ET SON UTILISATION POUR LA PREPARATION DE DERIVES DE PYRROLO 2,3-PYRIMIDINE UTILISES COMME INHIBITEURS DE PROTEINES KINASE
  申请人：PFIZER PROD INC

  公开号：WO2002096909A1

  公开（公告）日：2002-12-05

  A method for resolving enantiomers of a compound containing the structure of the formula (I): wherein R4 or R5 may contain one or more asymmetric centers, by mixing a racemic mixture of enantiomers of a compound, containing the structure of said formula; in a solvent, with a resolving compound having a defined stereospecificity, to form a solution and with said resolving agent being capable of binding with at least one but not all of said enantiomers to form a precipitate, containing said at least one of said enantiomers in stereospecific form and collecting either the precipitate and purifying it or collecting the solution with contained other of said enantiomers and recrystalizing the enantiomer contained in said solution.

  一种用于分离含有公式（I）结构的化合物的对映异构体的方法，其中R4或R5可能包含一个或多个不对称中心，通过将含有该公式结构的化合物的对映异构体的混合物与一个具有定义的立体特异性的分离剂混合在溶剂中，形成溶液，所述分离剂能够与至少一个但不是全部的对映异构体结合形成沉淀，其中包含所述至少一个对映异构体的立体特异形式，并收集沉淀并纯化它，或收集所述溶液并重新结晶所述溶液中所含的其他对映异构体并分离所述溶液中所含的所述对映异构体。
• Alanyl-piperidine heterocyclic derivatives useful against cardiovascular diseases
  申请人：——

  公开号：US20040254374A1

  公开（公告）日：2004-12-16

  Compounds of formula (I) 1 in which R 1 , R 2 , n and X 1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.

  式(I)的化合物1，其中R1，R2，n和X1具有规范中给定的含义，是治疗血栓性疾病中有用的因子Xa抑制剂。
• Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists
  申请人：Tung S. Jay

  公开号：US20050038099A1

  公开（公告）日：2005-02-17

  Disclosed are compounds that are bradykinin B 1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B 1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.

  本发明涉及一种是Bradykinin B1受体拮抗剂的化合物，可用于治疗哺乳动物中由Bradykinin B1受体介导的疾病或缓解与疾病状况相关的不良症状。其中某些化合物表现出增强的效力，并且预计还会表现出持续时间的增加。