6-Amino-3,3,5,5-tetramethyl-6-oxohexanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-Amino-3,3,5,5-tetramethyl-6-oxohexanoic acid
• 英文别名: 6-amino-3,3,5,5-tetramethyl-6-oxohexanoic acid
• 化学式: C₁₀H₁₉NO₃
• 分子量: 201.26
• InChiKey: SAHYFDMQANDYCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Polymer-carbohydrate conjugates for drug delivery technology
  申请人：Wu Nian

  公开号：US10835608B2

  公开（公告）日：2020-11-17

  The invention comprises compounds, methods of making, and methods of using. The compounds may have a linear or cylic backbone and three or four appended functional groups: one or two lipohilic compounds including sterols or “fat soluble” vitamins, one or two hydrophilic polymer, and one or two carbohydrate. A group of polymer-carbohydrate conjugates having a central backbone and three appended functional groups are disclosed wherein one lipophilic compound is void of both steroid acids. The conjugate may have fatty acids as the primary lipophilic carrier, one hydrophilic polymer, and one carbohydrate. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. Typical coupling reaction of the conjugates may involve one or more or combinations or in series of alkylation including N-alkylation or O-alkylation, etherification, esterification and amidation chemical processes. A variety of linkers between the backbone and functional groups may also be selected to modify the carriers or center backbones for the coupling reactions and optimize performance of the conjugates.

  本发明包括化合物、制造方法和使用方法。这些化合物可具有线性或环状骨架和三个或四个附加官能团：一个或两个亲脂化合物（包括甾醇或 "脂溶性 "维生素）、一个或两个亲水性聚合物以及一个或两个碳水化合物。已公开的一组聚合物-碳水化合物共轭物具有一个中心骨架和三个附加官能团，其中一种亲脂化合物不含两种甾醇酸。共轭物可以脂肪酸为主要亲脂载体，一种亲水性聚合物和一种碳水化合物。可以选择特定的官能团，用于配制药品、化妆品、营养品等。共轭物的典型偶联反应可能涉及一种或多种烷基化反应，或其组合或系列烷基化反应，包括 N-烷基化反应或 O-烷基化反应、醚化反应、酯化反应和酰胺化反应等化学过程。还可在骨架和官能团之间选择各种连接物，以修饰用于偶联反应的载体或中心骨架，优化共轭物的性能。