2-piperazin-1-ium-1-ylbutanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-piperazin-1-ium-1-ylbutanoate
• 化学式: C8H16N2O2
• 分子量: 172.22
• InChiKey: WQPQOMYHQHFIIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Compositions, Synthesis, And Methods Of Using Piperazine Based Antipsychotic Agents
  申请人：Bhat Laxminarayan

  公开号：US20090298819A1

  公开（公告）日：2009-12-03

  The present invention provides novel piperazine derivatives which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder and depression.

  本发明提供了一种新颖的哌嗪衍生物，可以优势地用于治疗精神分裂症和相关精神病，如急性躁狂、双相情感障碍、自闭症和抑郁症。
• Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto
  申请人：——

  公开号：US20030220330A1

  公开（公告）日：2003-11-27

  Compounds having activity as inhibitors of the JNK pathway are disclosed. The compounds of this invention are anilinopyrimidine derivatives having the following structure: 1 wherein R 1 through R 6 are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to inhibition of the JNK pathway. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

  本发明揭示了作为JNK通路抑制剂活性的化合物。本发明的化合物是具有以下结构的苯胺吡嘧啶衍生物：其中R1至R6如本文所定义。这些化合物在治疗对JNK通路抑制敏感的广泛疾病方面具有用途。因此，本文还揭示了治疗这些疾病的方法，以及含有上述化合物中的一个或多个化合物的药物组合物。
• Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
  申请人：——

  公开号：US20030203926A1

  公开（公告）日：2003-10-30

  Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure: 1 wherein R 1 and R 6 are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to IKK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

  本发明揭示了作为IKK抑制剂的化合物，特别是IKK-2。本发明的化合物是具有以下结构的苯胺嘧啶衍生物：1其中R1和R6如本文所定义。这些化合物在治疗对IKK抑制有响应的各种疾病方面具有实用性。因此，本文还揭示了治疗这些疾病的方法，以及含有上述化合物之一或多个化合物的药物组合物。
• Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
  申请人：——

  公开号：US20040106634A1

  公开（公告）日：2004-06-03

  This invention generally relates to methods for treating or preventing a condition responsive to JNK inhibition, such as a metabolic condition, comprising administering to a patient in need thereof an effective amount of an Anilinopyrimidine Derivative having the following structure: 1 or a pharmaceutically acceptable salt thereof, wherein R 1 through R 6 are as defined herein.

  这项发明通常涉及用于治疗或预防对JNK抑制敏感的疾病的方法，例如代谢状况，包括向需要的患者施用具有以下结构的Anilinopyrimidine衍生物的有效剂量：1或其药用可接受盐，其中R1至R6如本文所定义。
• [EN] NEW BENZIMIDAZOLE DERIVATIVES A PROCESS FOR PRODUCTION THEREOF AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：AKTIEBOLAGET HÄSSLE

  公开号：WO1988003921A1

  公开（公告）日：1988-06-02

  (EN) Novel compounds of formula (I), pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.(FR) Nouveaux composés représentés par la formule (I), compositions pharmaceutiques contenant de tels composés comme ingrédient actif et utilisation desdits composés en medecine.

  (I)式新化合物，包含此类化合物作为活性成分的药物组合物，以及该类化合物在医学上的应用。(FR)式新化合物，包含此类化合物作为活性成分的药物组合物，以及该类化合物在医学上的应用。