Propyl 4-(dimethylamino)butanoate | 67338-66-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Propyl 4-(dimethylamino)butanoate
• CAS: 67338-66-3
• 化学式: C₉H₁₉NO₂
• 分子量: 173.25
• InChiKey: GHAVQZQNAYGEDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Biodegradable lipids for the delivery of active agents
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US11382979B2

  公开（公告）日：2022-07-12

  The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  本发明涉及一种阳离子脂质，该阳离子脂质的脂质分子（如疏水链）中含有一个或多个可生物降解的基团。这些阳离子脂质可掺入脂质颗粒中，用于递送核酸等活性剂。本发明还涉及由中性脂质、能够减少聚集的脂质、本发明的阳离子脂质和可选的固醇组成的脂质颗粒。脂质微粒可进一步包括治疗剂，如核酸。
• BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20220175929A1

  公开（公告）日：2022-06-09

  The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.