苄氧羰基苯丙氨酰苯丙氨酸重氮基甲基甲酮

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 苄氧羰基苯丙氨酰苯丙氨酸重氮基甲基甲酮
• 英文名称: benzyl N-[(2S)-1-[[(2S,4E)-4-diazo-3-oxo-1-phenylbutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
• 化学式: C27H26N4O4
• 分子量: 470.5
• InChiKey: JIFSOVRQDDYNAH-ZEQRLZLVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  86.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Materials for cathepsin B enhancement and methods of use
  申请人：The University of North Carolina at Pembroke

  公开号：US10702571B2

  公开（公告）日：2020-07-07

  The present invention provides methods for treating a subject afflicted with a protein accumulation disease or TBI, comprising administering to the subject at least one compound that increases the level of active cathepsin B in cells of the subject, or a pharmaceutically acceptable salt or ester thereof, in an amount that is effective to treat the subject. The present invention also provides compositions for treating a subject afflicted with a protein accumulation disease or TBI.

  本发明提供了治疗受蛋白蓄积症或创伤性脑损伤困扰的受试者的方法，包括向受试者施用至少一种可增加受试者细胞中活性酪蛋白B水平的化合物或其药学上可接受的盐或酯，其用量对治疗受试者有效。本发明还提供了用于治疗蛋白蓄积症或创伤性脑损伤患者的组合物。
• MATERIALS FOR POSITIVE CATHEPSIN B MODULATION AND METHODS OF USE FOR TREATING MILD COGNITIVE IMPAIRMENT (MCI), EARLY DEMENTIA, A-SYNUCLEINOPATHY, TRAUMATIC BRAIN INJURY, CARDIOMYOPATHY, EYE DISEASE AND SKIN DAMAGE
  申请人：University of North Carolina at Pembroke

  公开号：EP3010532A1

  公开（公告）日：2016-04-27
• MATERIALS FOR CATHEPSIN B ENHANCEMENT AND METHODS OF USE
  申请人：Bahr Ben A.

  公开号：US20180264071A1

  公开（公告）日：2018-09-20

  The present invention provides methods for treating a subject afflicted with a protein accumulation disease or TBI, comprising administering to the subject at least one compound that increases the level of active cathepsin B in cells of the subject, or a pharmaceutically acceptable salt or ester thereof, in an amount that is effective to treat the subject. The present invention also provides compositions for treating a subject afflicted with a protein accumulation disease or TBI.
• [EN] METABOLIC TEST<br/>[FR] TEST METABOLIQUE
  申请人：PLYMOUTH MARINE APPLIC LTD

  公开号：WO2005106025A1

  公开（公告）日：2005-11-10

  A method for assessing growth efficiency of an organism by typing a peptidase/aminotransferase gene or protein of the organism.
• [EN] MATERIALS FOR POSITIVE CATHEPSIN B MODULATION AND METHODS OF USE FOR TREATING MILD COGNITIVE IMPAIRMENT (MCI), EARLY DEMENTIA, A-SYNUCLEINOPATHY, TRAUMATIC BRAIN INJURY, CARDIOMYOPATHY, EYE DISEASE AND SKIN DAMAGE<br/>[FR] MATÉRIAUX POUR LA MODULATION POSITIVE DE LA CATHEPSINE B ET MÉTHODES D'UTILISATION POUR LE TRAITEMENT D'UN TROUBLE COGNITIF LÉGER, D'UNE DÉMENCE PRÉCOCE, D'A-SYNUCLÉINOPATHIE, D'UNE LÉSION CÉRÉBRALE TRAUMATIQUE, D'UNE CARDIOMYOPATHIE, D'UNE MALADIE DE L'ŒIL ET D'UN DOMMAGE CUTANÉ
  申请人：UNIV NORTH CAROLINA AT PEMBROKE

  公开号：WO2014204956A1

  公开（公告）日：2014-12-24

  The present invention provides methods for treating a subject afflicted with i) Mild Cognitive Impairment (MCI), ii) early dementia, iii) early a-synucleinopathy, iv) traumatic brain injury, v) cardiomyopathy, vi) eye disease, or vii) skin damage, comprising administering to the subject at least one compound that increases the level of active cathepsin B in cells of the subject, or a pharmaceutically acceptable salt or ester thereof, in an amount that is effective to treat the subject. The present invention also provides compositions for treating a subject afflicted with i) Mild Cognitive Impairment (MCI), ii) early dementia, iii) early cx-synucleinopathy, iv) traumatic brain injury, v) cardiomyopathy, vi) eye disease, or vii) skin damage.