2',3'-O-isopropylidene-5'-O-(p-octyloxybenzoyl)uridine | 1234686-07-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2',3'-O-isopropylidene-5'-O-(p-octyloxybenzoyl)uridine
• 英文别名: [(3aR,4R,6R,6aR)-4-(2,4-dioxopyrimidin-1-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methyl 4-octoxybenzoate
• CAS: 1234686-07-7
• 化学式: C₂₇H₃₆N₂O₈
• 分子量: 516.591
• InChiKey: KGKZGVSZQKTJEZ-MSNJVRRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  37
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2',3'-O-isopropylidene-5'-O-(p-octyloxybenzoyl)uridine 在 盐酸 、 水 作用下， 以 丙酮 为溶剂， 反应 14.0h， 以87%的产率得到5'-O-(p-octyloxybenzoyl)uridine
  参考文献：
  名称：

  Synthesis of Novel 5′-Uridine-Head Amphiphiles as Model for DNA Molecular Recognition

  摘要：

  Here we describe uridine functionalization in the 5' position, which provides new classes of cationic and nonionic amphiphiles specifically designed. as DNA transfection agents. The Synthetic procedures developed to obtain the cationic uridine-head surfactants prevented intramolecular cyclization. that occurs when. uridine is functionalized in this position without using protecting groups in the uracil.

  DOI：

  10.1080/15257770903306625
• 作为产物：
  描述：

  对辛氧基苯甲酰氯 、 2’,3’邻异亚丙基尿苷 在 吡啶 作用下， 以80%的产率得到2',3'-O-isopropylidene-5'-O-(p-octyloxybenzoyl)uridine
  参考文献：
  名称：

  Synthesis of Novel 5′-Uridine-Head Amphiphiles as Model for DNA Molecular Recognition

  摘要：

  Here we describe uridine functionalization in the 5' position, which provides new classes of cationic and nonionic amphiphiles specifically designed. as DNA transfection agents. The Synthetic procedures developed to obtain the cationic uridine-head surfactants prevented intramolecular cyclization. that occurs when. uridine is functionalized in this position without using protecting groups in the uracil.

  DOI：

  10.1080/15257770903306625

文献信息

• Synthesis of Novel 5′-Uridine-Head Amphiphiles as Model for DNA Molecular Recognition
  作者：Matteo Tiecco、Pietro Di Profio、Raimondo Germani、Gianfranco Savelli

  DOI：10.1080/15257770903306625

  日期：2009.10.28

  Here we describe uridine functionalization in the 5' position, which provides new classes of cationic and nonionic amphiphiles specifically designed. as DNA transfection agents. The Synthetic procedures developed to obtain the cationic uridine-head surfactants prevented intramolecular cyclization. that occurs when. uridine is functionalized in this position without using protecting groups in the uracil.