2,4-dimethyl-6-(pent-4-enyl)pyrimidine | 1191954-59-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,4-dimethyl-6-(pent-4-enyl)pyrimidine
• 英文别名: 2,4-Dimethyl-6-pent-4-enylpyrimidine；2,4-dimethyl-6-pent-4-enylpyrimidine
• CAS: 1191954-59-2
• 化学式: C₁₁H₁₆N₂
• 分子量: 176.261
• InChiKey: HAQGBXMIVJYUIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  己基溴化镁 、 2,6-dimethyl-4-pyrimidinyl p-toluenesulfonate 在 iron(III) chloride 作用下， 以 四氢呋喃 、 N-甲基吡咯烷酮 为溶剂， 以92%的产率得到2,4-dimethyl-6-(pent-4-enyl)pyrimidine
  参考文献：
  名称：

  Heteroaromatic Sulfonates and Phosphates as Electrophiles in Iron-Catalyzed Cross-Couplings

  摘要：

  Employment of heteroaromatic tosylates and phosphates as suitable electrophiles in iron-catalyzed cross-coupling reactions with alkyl Grignard reagents is reported. These reactions are performed at low temperature allowing good functional group tolerance and full conversion is achieved within minutes. In addition, an aryl-aryl cross-coupling utilizing a heteroaryl sulfamate electrophile is reported.

  DOI：

  10.1021/ol901975u

文献信息

• Heteroaromatic Sulfonates and Phosphates as Electrophiles in Iron-Catalyzed Cross-Couplings
  作者：Thomas M. Gøgsig、Anders T. Lindhardt、Troels Skrydstrup

  DOI：10.1021/ol901975u

  日期：2009.11.5

  Employment of heteroaromatic tosylates and phosphates as suitable electrophiles in iron-catalyzed cross-coupling reactions with alkyl Grignard reagents is reported. These reactions are performed at low temperature allowing good functional group tolerance and full conversion is achieved within minutes. In addition, an aryl-aryl cross-coupling utilizing a heteroaryl sulfamate electrophile is reported.